Evidence map›Paper›PMID 26929652›Full record

ArticleJournal of asthma and allergy2016

The asthma-COPD overlap syndrome: how is it defined and what are its clinical implications?

Maarten van den Berge, René Aalbers

Abstract read
In one paragraph

Article in Journal of asthma and allergy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Canadian family physician Medecin de famille canadien · 2021
    Article
  3. Article
  4. Article
  5. Prevalence of COPD among workers with work-related asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2020
    Article
  6. Observational
  7. Article
  8. Asthma medication use among adults with current asthma by work-related asthma status, Asthma Call-back Survey, 29 states, 2012-2013.The Journal of asthma : official journal of the Association for the Care of Asthma · 2018
    Article
  9. Article
  10. Use of clinical characteristics to predict spirometric classification of obstructive lung disease.International journal of chronic obstructive pulmonary disease · 2018
    Article
  11. Health characteristics of patients with asthma, COPD and asthma-COPD overlap in the NHANES database.International journal of chronic obstructive pulmonary disease · 2018
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Maarten van den BergeDepartment of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
René AalbersDepartment of Pulmonary Diseases, Martini Hospital, Groningen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is increasingly recognized that both asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous diseases with a large inter-individual variability with respect to their clinical expression, disease progression, and responsiveness to the available treatments. The introduction of asthma-COPD overlap syndrome (ACOS) may lead to a better clinical characterization and improved treatment of patients with obstructive airways disease. However, it is still in its early phase and several improvements will have to be made. First, a clear definition of ACOS and preferably also its sub-phenotypes, eg, asthma-ACOS and COPD-ACOS, is urgently needed. That would also allow researchers to design clinical studies in well-defined patients. The latter is important since the interpretation of clinical studies performed so far is hampered by the use of many different definitions of ACOS. Second, future studies are needed to investigate the role of state-of-the-art techniques such as computed tomography, genetics, and genomics in the phenotyping of patients with obstructive airways disease, ie, asthma, COPD, and ACOS. Third, longitudinal studies are now needed to better define the clinical implications of ACOS with respect to the long-term outcome and treatment of ACOS and its sub-phenotypes compared to only asthma or COPD.

Indexed as

ACOSasthmaCOPDinflammationoverlap phenotyperemodeling

Identifiers

PMID26929652
PMCPMC4755465

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.