ArticleThe Journal of biological chemistry2016
Regulation of Piezo2 Mechanotransduction by Static Plasma Membrane Tension in Primary Afferent Neurons.
Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 47 citations in OpenAlex.
- Dietary Microplastics Engage Gut Mechanosensory-Endocrine Signaling to Disrupt Bone Homeostasis.bioRxiv : the preprint server for biology · 2026Article
- Neuromechanobiology: Bridging Mechanobiology and Neuroscience Through Evidence and Open Questions.Cells · 2026Review
- Mechanobiological Dynamics-Inspired Mechanomodulatory Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Spontaneous calcium transients in hair cell stereocilia.Scientific reports · 2025Article
- Investigating Mechanically Activated Currents from Trigeminal Neurons of Nonhuman Primates.eNeuro · 2025Article
- Piezo2 interacts with E-cadherin in specialized gastrointestinal epithelial mechanoreceptors.The Journal of general physiology · 2024Article
- Review
- Potentiation of PIEZO2 mechanically-activated currents in sensory neurons mediates vincristine-induced mechanical hypersensitivity.Acta pharmaceutica Sinica. B · 2023Article
- Miswired Proprioception in Amyotrophic Lateral Sclerosis in Relation to Pain Sensation (and in Delayed Onset Muscle Soreness)-Is Piezo2 Channelopathy a Principal Transcription Activator in Proprioceptive Terminals Besides Being the Potential Primary Damage?Life (Basel, Switzerland) · 2023Article
- The energetics of rapid cellular mechanotransduction.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- TMEM120A/TACAN inhibits mechanically activated PIEZO2 channels.The Journal of general physiology · 2022Article
- Molecular determinants of mechanosensation in the muscle spindle.Current opinion in neurobiology · 2022Review
- Mechanical and chemical activation of GPR68 probed with a genetically encoded fluorescent reporter.Journal of cell science · 2021Article
- Role of microtubules in Piezo2 mechanotransduction of mouse Merkel cells.Journal of neurophysiology · 2020Article
- Selective impairment of slowly adapting type 1 mechanoreceptors in mice following vincristine treatment.Neuroscience letters · 2020Article
- Mechanosensing and Mechanoregulation of Endothelial Cell Functions.Comprehensive Physiology · 2019Review
- Neuropathic pain in a Fabry disease rat model.JCI insight · 2018Article
- Article
- Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells.Scientific reports · 2018Article
- Molecular basis of tactile specialization in the duck bill.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
The Piezo2 channel is a newly identified mammalian mechanical transducer that confers rapidly adapting mechanically activated (RA-MA) currents in primary afferent neurons. The Piezo2 channels sense rapid membrane displacement, but it is not clear whether they are sensitive to osmotic swelling, which slowly increases static plasma membrane tension (SPMT). Here, we show that SPMT exerts a profound impact on the mechanical sensitivity of RA-MA channels in primary afferent neurons. RA-MA currents are greatly enhanced, and the mechanical threshold was reduced in both primary afferent neurons of rat dorsal root ganglia (DRG) and HEK293 cells heterologously expressing Piezo2 when these cells undergo osmotic swelling to increase SPMT. Osmotic swelling switches the kinetics of RA-MA currents to the slowly adapting type in both cultured DRG neurons and HEK293 cells heterologously expressing Piezo2. The potentiation of RA-MA currents is abolished when cultured DRG neurons are treated with cytochalasin D, an actin filament disruptor that prevents SPMT of cultured DRG neurons from an increase by osmotic swelling. Osmotic swelling significantly increases DRG neuron mechano-excitability such that a subthreshold mechanical stimulus can result in action potential firing. Behaviorally, the mechanical hind paw withdrawal threshold in rats is reduced following the injection of a hypotonic solution, but this osmotic effect is abolished when cytochalasin D or Gd(3+) is co-administered with the hypo-osmotic solution. Taken together, our findings suggest that Piezo2-mediated mechanotransduction is regulated by SPMT in primary afferent neurons. Because SPMT can be changed by multiple biological factors, our findings may have broad implications in mechanical sensitivity under physiological and pathological conditions.
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