ArticleProceedings of the National Academy of Sciences of the United States of America2016
Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 2 of them syntheses that pooled it.
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Who cites it
86 citing papers in PubMed, 2 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- Prevalence and factors associated with restless legs syndrome among pregnant women in middle-income countries: a systematic review and meta-analysis.Frontiers in medicine · 2023Pooled it
- Association of transferrin G258A and transferrin receptor A82G polymorphisms with the risk of Parkinson disease in certain area.Medicine · 2020Pooled it
- High prevalence of kaolin consumption in migrant women living in a major urban area of France: A cross-sectional investigation.PloS one · 2019Trial
- The role of subcortical brain tissue iron as an indicator of dopamine neurophysiology in adolescent cannabis use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Iron Deficiency Impairs Mitochondrial Energetics and Early Axonal Growth and Branching in Developing Hippocampal Neurons.The Journal of nutrition · 2026Article
- Effect of 6-Hydroxydopamine on Iron Metabolism in MO3.13 Oligodendrocytes.Neurochemical research · 2026Article
- Iron deficiency induces maturation-dependent loss of pancreatic β-cells.Nature communications · 2026Article
- Subacute Iron Exposure in Rats Induces Behavioral Impairments, Oxidative Stress, and Histopathological Alterations.Journal of molecular neuroscience : MN · 2026Article
- Isn't it ironic? Functional iron deficiency at the core of Parkinson's disease pathobiology.The Journal of clinical investigation · 2026Article
- Chorioamnionitis Induces a Unique Time Course of Inflammatory Changes and Immune Reponses in the Brain and Spleen.Developmental neuroscience · 2026Article
- Iron Deficiency Impairs Mitochondrial Energetics and Early Axonal Growth and Branching in Developing Hippocampal Neurons.bioRxiv : the preprint server for biology · 2025Article
- FAM210B regulates iron homeostasis and sex-specific responses in stress erythropoiesis.Experimental hematology · 2025Article
- Transferrin receptor 1 deficiency in smooth muscle cells attenuates vascular remodeling in hypertensive mice.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Bone phenotype in male and female mice after knockdown of transferrin receptor 1 in osterix-expressing cells.JBMR plus · 2025Article
- Iron in the migraine brain.Histology and histopathology · 2025Review
- Exploring the role of mitochondrial dysfunction and aging in COVID-19-Related neurological complications.Molecular biology reports · 2025Review
- FAM210B Regulates Iron Homeostasis and Sex-Specific Responses in Stress Erythropoiesis.bioRxiv : the preprint server for biology · 2025Article
- Ferroptosis and Iron Homeostasis: Molecular Mechanisms and Neurodegenerative Disease Implications.Antioxidants (Basel, Switzerland) · 2025Review
- Nigrostriatal iron accumulation in the progression of Parkinson's disease.NPJ Parkinson's disease · 2025Article
- The essential clathrin adapter protein complex-2 is tumor suppressive specifically in vivo.Nature communications · 2025Article
26 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Disrupted brain iron homeostasis is a common feature of neurodegenerative disease. To begin to understand how neuronal iron handling might be involved, we focused on dopaminergic neurons and asked how inactivation of transport proteins affected iron homeostasis in vivo in mice. Loss of the cellular iron exporter, ferroportin, had no apparent consequences. However, loss of transferrin receptor 1, involved in iron uptake, caused neuronal iron deficiency, age-progressive degeneration of a subset of dopaminergic neurons, and motor deficits. There was gradual depletion of dopaminergic projections in the striatum followed by death of dopaminergic neurons in the substantia nigra. Damaged mitochondria accumulated, and gene expression signatures indicated attempted axonal regeneration, a metabolic switch to glycolysis, oxidative stress, and the unfolded protein response. We demonstrate that loss of transferrin receptor 1, but not loss of ferroportin, can cause neurodegeneration in a subset of dopaminergic neurons in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.