ArticleProceedings of the National Academy of Sciences of the United States of America2016
Importin-7 mediates memory consolidation through regulation of nuclear translocation of training-activated MAPK in Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Spacing effect improves generalization in biological and artificial systems.Patterns (New York, N.Y.) · 2026Article
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- Identification of Genes Responding to Iron or Choline Treatment for Early-Life Iron Deficiency in the Male Rat Hippocampal Transcriptomes.The Journal of nutrition · 2024Article
- Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinα1/KPNA2.EMBO molecular medicine · 2023Article
- A behavioral tagging account of kinase contribution to memory formation after spaced aversive training.iScience · 2023Article
- Inhibition of importin-7 attenuates ventilator-induced lung injury by targeting nuclear translocation of p38.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Article
- CREBB repression of protein synthesis in mushroom body gates long-term memory formation inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Exclusion and Co-expression of Aversive Olfactory Long-Term Memories in Drosophila.Neuroscience bulletin · 2022Article
- Contributions of extracellular-signal regulated kinase 1/2 activity to the memory trace.Frontiers in molecular neuroscience · 2022Review
- Article
- Dopamine Receptor Dop1R2 Stabilizes Appetitive Olfactory Memory through the Raf/MAPK Pathway inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Spatial-Memory Formation After Spaced Learning Involves ERKs1/2 Activation Through a Behavioral-Tagging Process.Scientific reports · 2020Article
- The neural circuit linking mushroom body parallel circuits induces memory consolidation inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Elongator complex is required for long-term olfactory memory formation inLearning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- A kinase-dependent feedforward loop affects CREBB stability and long term memory formation.eLife · 2018Article
- Preferential distribution of nuclear MAPK signal in α/β core neurons during long-term memory consolidation in Drosophila.Protein & cell · 2017Article
- The Spacing Effect for Structural Synaptic Plasticity Provides Specificity and Precision in Plastic Changes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Appetitive Olfactory Learning and Long-Term Associative Memory inFrontiers in behavioral neuroscience · 2017Article
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8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Translocation of signaling molecules, MAPK in particular, from the cytosol to nucleus represents a universal key element in initiating the gene program that determines memory consolidation. Translocation mechanisms and their behavioral impact, however, remain to be determined. Here, we report that a highly conserved nuclear transporter, Drosophila importin-7 (DIM-7), regulates import of training-activated MAPK for consolidation of long-term memory (LTM). We show that silencing DIM-7 functions results in impaired LTM, whereas overexpression of DIM-7 enhances LTM. This DIM-7-dependent regulation of LTM is confined to a consolidation time window and in mushroom body neurons. Image data show that bidirectional alteration in DIM-7 expression results in proportional changes in the intensity of training-activated MAPK accumulated within the nuclei of mushroom body neurons during LTM consolidation. Such DIM-7-regulated nuclear accumulation of activated MAPK is observed only in the training specified for LTM induction and determines the amplitude, but not the time course, of memory consolidation.
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