ArticleProceedings of the National Academy of Sciences of the United States of America2016
Material heterogeneity in cancellous bone promotes deformation recovery after mechanical failure.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Biomass-Derived Hydrogels for Load-Bearing Connective Tissue Repair: Integrative Reinforcement, Bio-Functional Design, and Emerging Pathways Toward Clinical Translation.Advanced healthcare materials · 2026Review
- Three-dimensional quantitative tissue clearing reveals differences in osteovascular niche of aged and young human mesenchymal stromal cells.Nature biomedical engineering · 2026Article
- A 50-year perspective on the use and potential of artiodactyl calcanei in bone adaptation studies.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Next-Generation Joint-on-a-Chip: Toward Precision Mechanical Control in Multi-Tissue Systems.Nano-micro letters · 2026Review
- Image-Based Polygonal Lattices for Mechanical Modeling of Biological Materials: 2D Demonstrations.ACS biomaterials science & engineering · 2023Article
- Finite element analysis of bone mechanical properties using MRI-derived bound and pore water concentration maps.Computer methods in biomechanics and biomedical engineering · 2023Article
- Suppression of Remodeling and Bone Fragility.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- Increased Advanced Glycation Endproducts, Stiffness, and Hardness in Iliac Crest Bone From Postmenopausal Women With Type 2 Diabetes Mellitus on Insulin.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- Animal Models of Bone Marrow Lesions in Osteoarthritis.JBMR plus · 2022Review
- Bone-inspired microarchitectures achieve enhanced fatigue life.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Mechanical Characterization of Bone: State of the Art in Experimental Approaches-What Types of Experiments Do People Do and How Does One Interpret the Results?Current osteoporosis reports · 2018Review
- Bone marrow lesions in osteoarthritis: What lies beneath.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Review
- Bone Mechanical Properties in Healthy and Diseased States.Annual review of biomedical engineering · 2018Review
- The Role of Matrix Composition in the Mechanical Behavior of Bone.Current osteoporosis reports · 2018Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Many natural structures use a foam core and solid outer shell to achieve high strength and stiffness with relatively small amounts of mass. Biological foams, however, must also resist crack growth. The process of crack propagation within the struts of a foam is not well understood and is complicated by the foam microstructure. We demonstrate that in cancellous bone, the foam-like component of whole bones, damage propagation during cyclic loading is dictated not by local tissue stresses but by heterogeneity of material properties associated with increased ductility of strut surfaces. The increase in surface ductility is unexpected because it is the opposite pattern generated by surface treatments to increase fatigue life in man-made materials, which often result in reduced surface ductility. We show that the more ductile surfaces of cancellous bone are a result of reduced accumulation of advanced glycation end products compared with the strut interior. Damage is therefore likely to accumulate in strut centers making cancellous bone more tolerant of stress concentrations at strut surfaces. Hence, the structure is able to recover more deformation after failure and return to a closer approximation of its original shape. Increased recovery of deformation is a passive mechanism seen in biology for setting a broken bone that allows for a better approximation of initial shape during healing processes and is likely the most important mechanical function. Our findings suggest a previously unidentified biomimetic design strategy in which tissue level material heterogeneity in foams can be used to improve deformation recovery after failure.
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