Evidence map›Paper›PMID 26929236›Full record

ReviewThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry2017

Functional Connectivity of the Infant Human Brain: Plastic and Modifiable.

Wei Gao, Weili Lin, Karen Grewen, John H Gilmore

Abstract readReview
In one paragraph

Review in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 166 papers.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

166 citing papers in PubMed.

  1. Trial
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  4. Altered connectivity and network efficiency in preterm infants.Cerebral cortex (New York, N.Y. : 1991) · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Disrupted Brain Connectivity in Newborns Following Antenatal Opioid Exposure.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026
    Observational
  12. Article
  13. Article
  14. Early-life neural correlates of behavioral inhibition and anxiety risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  15. Article
  16. Variation in high-amplitude events across the human lifespan.Network neuroscience (Cambridge, Mass.) · 2026
    Article
  17. Review
  18. Review
  19. Article
  20. Article

106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wei Gao1 Biomedical Imaging Research Institute (BIRI), Department of Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Weili Lin2 Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, NC, USA.
Karen Grewen3 Departments of Psychiatry, Neurobiology, and Psychology, University of North Carolina at Chapel Hill, NC, USA.
John H Gilmore4 Department of Psychiatry, University of North Carolina at Chapel Hill, NC, USA.

Funding

Prospective study of the onset of schizophreniaP50MH064065 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILMORE, JOHN HORACE · 2002 to 2011
$19.6M
Early Brain Development in One and Two Year OldsR01HD053000 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILMORE, JOHN HORACE · 2007 to 2018
$4.4M
Creating Normative Functional Brain Atlases During InfancyR21NS088975 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI GAO, WEI, LIN, WEILI · 2015 to 2016
$447k
Prenatal cocaine exposure and functional connectivity in early infancyR03DA036645 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GAO, WEI, GREWEN, KAREN M · 2014 to 2014
$228k
NICHD NIH HHS R01 HD053000NIDA NIH HHS R03 DA036645NIMH NIH HHS P50 MH064065NINDS NIH HHS R21 NS088975
6 · The paper itself

Abstract

Infancy is a critical and immensely important period in human brain development. Subtle changes during this stage may be greatly amplified with the unfolding of different developmental processes, exerting far-reaching consequences. Studies of the structure and behavioral manifestations of the infant brain are fruitful. However, the specific functional brain mechanisms that enable the execution of different behaviors remained elusive until the advent of functional connectivity fMRI (fcMRI), which provides an unprecedented opportunity to probe the infant functional brain development in vivo. Since its inception, a burgeoning field of infant brain functional connectivity study has emerged and thrived during the past decade. In this review, we describe (1) findings of normal development of functional connectivity networks and their relationships to behaviors and (2) disruptions of the normative functional connectivity development due to identifiable genetic and/or environmental risk factors during the first 2 years of human life. Technical considerations of infant fcMRI are also provided. It is our hope to consolidate previous findings so that the field can move forward with a clearer picture toward the ultimate goal of fcMRI-based objective methods for early diagnosis/identification of risks and evaluation of early interventions to optimize developing functional connectivity networks in this critical developmental window.

Indexed as

Child of Impaired ParentsBrainChild DevelopmentConnectomeFemaleHumansInfantInfant, PrematureNerve NetNeuronal PlasticityPregnancyPrenatal Exposure Delayed Effectsearly brain developmentfunctional connectivityfunctional networksgenetic riskspremature birthprenatal drug exposureresting state

Identifiers

PMID26929236
PMCPMC5145769

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.