ArticleHuman brain mapping2016
Combining tract- and atlas-based analysis reveals microstructural abnormalities in early Tourette syndrome children.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Microstructural Abnormalities of White Matter Across Tourette Syndrome: A Voxel-Based Meta-Analysis of Fractional Anisotropy.Frontiers in neurology · 2021Pooled it
- White matter microstructural abnormalities in children with Tourette syndrome using tract-based spatial statistics analysis.Japanese journal of radiology · 2026Article
- Association between white matter structural damage and cognitive impairment in patients with cerebral small vessel disease based on TBSS technology.Frontiers in neurology · 2025Article
- Vitamin D3 improves iminodipropionitrile-induced tic-like behavior in rats through regulation of GDNF/c-Ret signaling activity.European child & adolescent psychiatry · 2024Article
- Imaging of the superficial white matter in health and disease.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- The microstructural change of the brain and its clinical severity association in pediatric Tourette syndrome patients.Journal of neurodevelopmental disorders · 2023Article
- Theta Activity Dynamics during Embedded Response Plan Processing in Tourette Syndrome.Biomedicines · 2023Article
- Brain volumes and white matter microstructure in 8- to 10-year-old children born with fetal growth restriction.Pediatric radiology · 2022Article
- Characterization of Brain Microstructural Abnormalities in High Myopia Patients: A Preliminary Diffusion Kurtosis Imaging Study.Korean journal of radiology · 2021Article
- Altered frontal-mediated inhibition and white matter connectivity in pediatric chronic tic disorders.Experimental brain research · 2021Article
- Inhibitory control in children with tic disorder: aberrant fronto-parietal network activity and connectivity.Brain communications · 2021Article
- Characteristics of diffusion tensor imaging of central nervous system in children with tourette's disease.Medicine · 2020Observational
- A Rare NovelFrontiers in psychiatry · 2020Article
- Neural activation and connectivity during cued eye blinks in Chronic Tic Disorders.NeuroImage. Clinical · 2019Article
- Combining Disrupted and Discriminative Topological Properties of Functional Connectivity Networks as Neuroimaging Biomarkers for Accurate Diagnosis of Early Tourette Syndrome Children.Molecular neurobiology · 2018Article
- Short-range connections in the developmental connectome during typical and atypical brain maturation.Neuroscience and biobehavioral reviews · 2017Review
- Altered topology of structural brain networks in patients with Gilles de la Tourette syndrome.Scientific reports · 2017Article
- Disrupted topological organization of structural networks revealed by probabilistic diffusion tractography in Tourette syndrome children.Human brain mapping · 2017Article
- Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study.Scientific reports · 2017Article
- Tourette syndrome research highlights from 2016.F1000Research · 2017Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tourette syndrome (TS) is a neurological disorder that causes uncontrolled repetitive motor and vocal tics in children. Examining the neural basis of TS churned out different research studies that advanced our understanding of the brain pathways involved in its development. Particularly, growing evidence points to abnormalities within the fronto-striato-thalamic pathways. In this study, we combined Tract-Based Spatial Statistics (TBSS) and Atlas-based regions of interest (ROI) analysis approach, to investigate the microstructural diffusion changes in both deep and superficial white matter (SWM) in TS children. We then characterized the altered microstructure of white matter in 27 TS children in comparison with 27 age- and gender-matched healthy controls. We found that fractional anisotropy (FA) decreases and radial diffusivity (RD) increases in deep white matter (DWM) tracts in cortico-striato-thalamo-cortical (CSTC) circuit as well as SWM. Furthermore, we found that lower FA values and higher RD values in white matter regions are correlated with more severe tics, but not tics duration. Besides, we also found both axial diffusivity and mean diffusivity increase using Atlas-based ROI analysis. Our work may suggest that microstructural diffusion changes in white matter is not only restricted to the gray matter of CSTC circuit but also affects SWM within the primary motor and somatosensory cortex, commissural and association fibers. Hum Brain Mapp 37:1903-1919, 2016. © 2016 Wiley Periodicals, Inc.
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