Evidence map›Paper›PMID 26929162›Full record

ReviewBJOG : an international journal of obstetrics and gynaecology2016

Low dose aspirin and pregnancy: how important is aspirin resistance?

K Navaratnam, A Alfirevic, Z Alfirevic

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BJOG : an international journal of obstetrics and gynaecology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 55 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. BMJ open · 2018
    Trial
  5. Trial
  6. Review
  7. Observational
  8. First Trimester Preeclampsia Screening and Prevention: Perspective in Chinese Mainland.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2024
    Article
  9. Review
  10. Thromboprophylaxis in Pregnant Women with COVID-19: An Unsolved Issue.International journal of environmental research and public health · 2023
    Review
  11. Review
  12. Article
  13. Review
  14. Low dose aspirin and pregnancy: how important is aspirin resistance?BJOG : an international journal of obstetrics and gynaecology · 2016
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

K NavaratnamCentre for Women's Health Research, Institute of Translation Medicine, University of Liverpool, Liverpool, UK.
A AlfirevicThe Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Z AlfirevicCentre for Women's Health Research, Institute of Translation Medicine, University of Liverpool, Liverpool, UK.
University of Liverpool · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledAntiplatelet agents are pivotal for prevention of coronary artery disease and cerebrovascular disease worldwide. Individual patient data meta-analysis indicates that low-dose aspirin causes a 10% risk reduction in pre-eclampsia for women at high individual risk. However, in the last 15 years it has emerged that a significant proportion of aspirin-treated individuals exhibit suboptimal platelet response, determined biochemically and clinically, termed 'aspirin non-responsiveness', 'aspirin resistance' and 'aspirin treatment failure'. More recently, investigation of aspirin responsiveness has begun in pregnant women. This review explores the history and clinical relevance of 'aspirin resistance' applied to high-risk obstetric populations. TWEETABLE ABSTRACT: Is 'aspirin resistance' clinically relevant in high-risk obstetrics?

Indexed as

Bleeding TimeMedication AdherenceAspirinBlood PlateletsDose-Response Relationship, DrugDrug ResistanceFemaleHumansPharmacogenomic VariantsPlatelet Aggregation InhibitorsPlatelet Function TestsPre-EclampsiaPregnancyPregnancy, High-RiskTreatment FailureAspirinPlatelet Aggregation InhibitorsActivationaspirinplateletpre-eclampsiapregnancyresistance

Identifiers

PMID26929162
PMCPMC5069612
OpenAlexW2288806715

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.