ArticleEnvironmental science & technology2016
Water Disinfection Byproducts Induce Antibiotic Resistance-Role of Environmental Pollutants in Resistance Phenomena.
Article in Environmental science & technology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- In vitro long-term exposure to chlorhexidine or triclosan induces cross-resistance against azoles in Nakaseomyces glabratus.Antimicrobial resistance and infection control · 2025Article
- Nonlinear impacts of temperature on antibiotic resistance inEnvironmental science and ecotechnology · 2024Article
- Article
- Co-selection for antibiotic resistance by environmental contaminants.npj antimicrobials and resistance · 2024Review
- Evaluation of Potential Factors Influencing the Dissemination of Multidrug-ResistantTropical medicine and infectious disease · 2023Review
- Screening ofMicroorganisms · 2023Article
- Beyond cyanotoxins: increasedFrontiers in microbiology · 2023Article
- Mobile resistome of microbial communities and antimicrobial residues from drinking water supply systems in Rio de Janeiro, Brazil.Scientific reports · 2022Article
- Synthesis and Property Examination of ErMaterials (Basel, Switzerland) · 2022Article
- Molecular mechanism of antibiotic resistance induced by mono- and twin-chained quaternary ammonium compounds.The Science of the total environment · 2022Article
- Development of bacterial resistance induced by low concentration of two-dimensional black phosphorusRSC advances · 2022Article
- Subinhibitory Concentration of Colistin Promotes the Conjugation Frequencies ofMicrobiology spectrum · 2022Article
- The influence of antibiotics on the anammox process - a review.Environmental science and pollution research international · 2022Review
- Biocide-tolerance and antibiotic-resistance in community environments and risk of direct transfers to humans: Unintended consequences of community-wide surface disinfecting during COVID-19?Environmental pollution (Barking, Essex : 1987) · 2021Review
- Metagenomic insights into dissemination of antibiotic resistance across bacterial genera in wastewater treatment.Chemosphere · 2021Article
- Stable dechlorination of Trichloroacetic Acid (TCAA) to acetic acid catalyzed by palladium nanoparticles deposited on HWater research · 2021Article
- Acceleration of emergence of E. coli antibiotic resistance in a simulated sublethal concentration of copper and tetracycline co-contaminated environment.AMB Express · 2021Article
- High Concentration and Frequent Application of Disinfection Increase the Detection of Methicillin-ResistantFrontiers in medicine · 2021Article
- MoSRSC advances · 2020Article
- Response of the Bacterial Community and Antibiotic Resistance in Overnight Stagnant Water from a Municipal Pipeline.International journal of environmental research and public health · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The spread of antibiotic resistance represents a global threat to public health, and has been traditionally attributed to extensive antibiotic uses in clinical and agricultural applications. As a result, researchers have mostly focused on clinically relevant high-level resistance enriched by antibiotics above the minimal inhibitory concentrations (MICs). Here, we report that two common water disinfection byproducts (chlorite and iodoacetic acid) had antibiotic-like effects that led to the evolution of resistant E. coli strains under both high (near MICs) and low (sub-MIC) exposure concentrations. The subinhibitory concentrations of DBPs selected strains with resistance higher than those evolved under above-MIC exposure concentrations. In addition, whole-genome analysis revealed distinct mutations in small sets of genes known to be involved in multiple drug and drug-specific resistance, as well as in genes not yet identified to play role in antibiotic resistance. The number and identities of genetic mutations were distinct for either the high versus low sub-MIC concentrations exposure scenarios. This study provides evidence and mechanistic insight into the sub-MIC selection of antibiotic resistance by antibiotic-like environmental pollutants such as disinfection byproducts in water, which may be important contributors to the spread of global antibiotic resistance. The results from this study open an intriguing and profound question on the roles of large amount and various environmental contaminants play in selecting and spreading the antibiotics resistance in the environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.