ArticleScientific reports2016
Structural insights into Cydia pomonella pheromone binding protein 2 mediated prediction of potentially active semiochemicals.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Identification and Functional Characterization of the Leg-Enriched Chemosensory Protein PxylCSP9 inBiology · 2025Article
- Odorant-binding protein 84a-1 mediates detection of Guire No.82 mango volatiles inFrontiers in insect science · 2025Article
- Expression Pattern and Ligand Binding Characteristics Analysis of Chemosensory Protein SnitCSP2 fromInsects · 2023Article
- Comparative Genomics Provide Insights Into Function and Evolution of Odorant Binding Proteins inFrontiers in physiology · 2021Article
- Crystal structure of Epiphyas postvittana pheromone binding protein 3.Scientific reports · 2020Article
- Molecular and Functional Characterization of pheromone binding protein 1 from the Oriental Fruit Moth, Grapholita molesta (Busck).Scientific reports · 2018Article
- A chemosensory protein MsepCSP5 involved in chemoreception of oriental armywormInternational journal of biological sciences · 2018Article
- Pheromone Binding Protein EhipPBP1 Is Highly Enriched in the Male Antennae of the Seabuckthorn Carpenterworm and Is Binding to Sex Pheromone Components.Frontiers in physiology · 2018Article
- Functional Analysis of the Chemosensory Protein MsepCSP8 From the Oriental ArmywormFrontiers in physiology · 2018Article
- Antitumor effect of sikokianin C, a selective cystathionine β-synthase inhibitor, against human colon cancerMedChemComm · 2018Article
- Odorant Receptors and Odorant-Binding Proteins as Insect Pest Control Targets: A Comparative Analysis.Frontiers in physiology · 2018Review
- Structure-based discovery of potentially active semiochemicals for Cydia pomonella (L.).Scientific reports · 2016Article
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3 authors.
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Abstract
Given the advantages of behavioral disruption application in pest control and the damage of Cydia pomonella, due progresses have not been made in searching active semiochemicals for codling moth. In this research, 31 candidate semiochemicals were ranked for their binding potential to Cydia pomonella pheromone binding protein 2 (CpomPBP2) by simulated docking, and this sorted result was confirmed by competitive binding assay. This high predicting accuracy of virtual screening led to the construction of a rapid and viable method for semiochemicals searching. By reference to binding mode analyses, hydrogen bond and hydrophobic interaction were suggested to be two key factors in determining ligand affinity, so is the length of molecule chain. So it is concluded that semiochemicals of appropriate chain length with hydroxyl group or carbonyl group at one head tended to be favored by CpomPBP2. Residues involved in binding with each ligand were pointed out as well, which were verified by computational alanine scanning mutagenesis. Progress made in the present study helps establish an efficient method for predicting potentially active compounds and prepares for the application of high-throughput virtual screening in searching semiochemicals by taking insights into binding mode analyses.
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