ArticleBMC evolutionary biology2016
Identification of a Latin American-specific BabA adhesin variant through whole genome sequencing of Helicobacter pylori patient isolates from Nicaragua.
Article in BMC evolutionary biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Review
- Glycan-mediated adhesion mechanisms in antibiotic-resistant bacteria.BBA advances · 2025Article
- An ancient ecospecies of Helicobacter pylori.Nature · 2024Article
- Historical and Molecular Perspectives on the Presence ofInternational journal of molecular sciences · 2024Review
- Biomarker Characterization and Prediction of Virulence and Antibiotic Resistance fromBiomolecules · 2022Review
- Helicobacter pylori infection causes both protective and deleterious effects in human health and disease.Genes and immunity · 2021Review
- A 500-year tale of co-evolution, adaptation, and virulence: Helicobacter pylori in the Americas.The ISME journal · 2021Article
- Review
- Review of current diagnostic methods and advances inWorld journal of gastroenterology · 2019Review
- SV40 seroprevalence in two Latin American countries involved in field trials of candidate oral poliovaccines.The Journal of infection · 2019Article
- Article
- A GWAS on Helicobacter pylori strains points to genetic variants associated with gastric cancer risk.BMC biology · 2018Article
- [Research progress on genotyping ofZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2018Review
- Rapid evolution of thePeerJ · 2018Article
- Article
- Rapid evolution of distinct Helicobacter pylori subpopulations in the Americas.PLoS genetics · 2017Article
- Phylogenomics of ColombianGut pathogens · 2017Article
- Whole Genome Sequence and Phylogenetic Analysis ShowFrontiers in cellular and infection microbiology · 2017Article
- Comparative Analysis of TwoFrontiers in microbiology · 2016Article
- Genomic diversity ofGut microbesArticle
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHelicobacter pylori (H. pylori) is one of the most common bacterial infections in humans and this infection can lead to gastric ulcers and gastric cancer. H. pylori is one of the most genetically variable human pathogens and the ability of the bacterium to bind to the host epithelium as well as the presence of different virulence factors and genetic variants within these genes have been associated with disease severity. Nicaragua has particularly high gastric cancer incidence and we therefore studied Nicaraguan clinical H. pylori isolates for factors that could contribute to cancer risk.
methodsThe complete genomes of fifty-two Nicaraguan H. pylori isolates were sequenced and assembled de novo, and phylogenetic and virulence factor analyses were performed.
resultsThe Nicaraguan isolates showed phylogenetic relationship with West African isolates in whole-genome sequence comparisons and with Western and urban South- and Central American isolates using MLSA (Multi-locus sequence analysis). A majority, 77 % of the isolates carried the cancer-associated virulence gene cagA and also the s1/i1/m1 vacuolating cytotoxin, vacA allele combination, which is linked to increased severity of disease. Specifically, we also found that Nicaraguan isolates have a blood group-binding adhesin (BabA) variant highly similar to previously reported BabA sequences from Latin America, including from isolates belonging to other phylogenetic groups. These BabA sequences were found to be under positive selection at several amino acid positions that differed from the global collection of isolates.
conclusionThe discovery of a Latin American BabA variant, independent of overall phylogenetic background, suggests hitherto unknown host or environmental factors within the Latin American population giving H. pylori isolates carrying this adhesin variant a selective advantage, which could affect pathogenesis and risk for sequelae through specific adherence properties.
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