ArticleJournal of the American Chemical Society2016
From Suicide Enzyme to Catalyst: The Iron-Dependent Sulfide Transfer in Methanococcus jannaschii Thiamin Thiazole Biosynthesis.
Article in Journal of the American Chemical Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Rethinking Suicide Thi4 Thiazole Synthases: Comparative Genomic Insights and Pilot Functional Evidence.ACS omega · 2026Article
- Ectomycorrhizal fungi recruit hyphae-associated bacteria that metabolize thiamine to promote pine symbiosis.The ISME journal · 2026Article
- THI1 Gene Evolutionary Trends: A Comprehensive Plant-Focused Assessment via Data Mining and Large-Scale Analysis.Genome biology and evolution · 2024Article
- Assimilatory sulfate reduction in the marine methanogen Methanothermococcus thermolithotrophicus.Nature microbiology · 2023Article
- Directed Evolution of Aerotolerance in Sulfide-Dependent Thiazole Synthases.ACS synthetic biology · 2023Article
- The thiolation of uridine 34 in tRNA, which controls protein translation, depends on a [4Fe-4S] cluster in the archaeum Methanococcus maripaludis.Scientific reports · 2023Article
- Oxidative Dearomatization of PLP in Thiamin Pyrimidine Biosynthesis inJournal of the American Chemical Society · 2023Article
- Functional and comparative analysis ofPeerJ · 2023Article
- Combined transcriptome and metabolome analysis of Nerium indicum L. elaborates the key pathways that are activated in response to witches' broom disease.BMC plant biology · 2022Article
- Using continuous directed evolution to improve enzymes for plant applications.Plant physiology · 2022Article
- Structure and function of aerotolerant, multiple-turnover THI4 thiazole synthases.The Biochemical journal · 2021Article
- Synthesis of high-titer alka(e)nes in Yarrowia lipolytica is enabled by a discovered mechanism.Nature communications · 2020Article
- Potential for Applying Continuous Directed Evolution to Plant Enzymes: An Exploratory Study.Life (Basel, Switzerland) · 2020Article
- The Prodigal Compound: Return of Ribosyl 1,5-Bisphosphate as an Important Player in Metabolism.Microbiology and molecular biology reviews : MMBR · 2019Review
- Parts-Prospecting for a High-Efficiency Thiamin Thiazole Biosynthesis Pathway.Plant physiology · 2019Article
- Engineering Strategies to Boost Crop Productivity by Cutting Respiratory Carbon Loss.The Plant cell · 2019Review
- Nonredox thiolation in tRNA occurring via sulfur activation by a [4Fe-4S] cluster.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- ThiN as a Versatile Domain of Transcriptional Repressors and Catalytic Enzymes of Thiamine Biosynthesis.Journal of bacteriology · 2017Article
- The dehydroalanine effect in the fragmentation of ions derived from polypeptides.Journal of mass spectrometry : JMS · 2016Article
- Structural Basis for Iron-Mediated Sulfur Transfer in Archael and Yeast Thiazole Synthases.Biochemistry · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Bacteria and yeast utilize different strategies for sulfur incorporation in the biosynthesis of the thiamin thiazole. Bacteria use thiocarboxylated proteins. In contrast, Saccharomyces cerevisiae thiazole synthase (THI4p) uses an active site cysteine as the sulfide source and is inactivated after a single turnover. Here, we demonstrate that the Thi4 ortholog from Methanococcus jannaschii uses exogenous sulfide and is catalytic. Structural and biochemical studies on this enzyme elucidate the mechanistic details of the sulfide transfer reactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.