ReviewAdvances in dental research2016
Implant Surface Design Regulates Mesenchymal Stem Cell Differentiation and Maturation.
Review in Advances in dental research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Brushite-modified titanium surface elicits early osteointegrative gene expression signatures in human mesenchymal stem cells: insights from NGS analysis.Frontiers in bioengineering and biotechnology · 2026Article
- Physical cues influence the construction of the osteoimmune microenvironment: focus on the hematoma period.Regenerative biomaterials · 2026Review
- Characterization and biocompatibility evaluation of a Ti@HA-GO@IL-4 bioactive composite coating for guided bone regeneration in dental implant applications.BMC oral health · 2025Article
- Anti-Inflammatory and Osteogenic Effect of Phloroglucinol-Enriched Whey Protein Isolate Fibrillar Coating on Ti-6Al-4V Alloy.Polymers · 2025Article
- The Impact of Implant Surface Modifications on the Osseointegration Process: An Overview.Cureus · 2025Review
- Obesity prolongs the pro-inflammatory response and attenuates bone healing on titanium implants.Acta biomaterialia · 2025Article
- Navigating the Immunological Crossroads: Mesenchymal Stem/Stromal Cells as Architects of Inflammatory Harmony in Tissue-Engineered Constructs.Bioengineering (Basel, Switzerland) · 2024Review
- CD4Acta biomaterialia · 2024Article
- Modeling of a New Percutaneous Orthopedic Implant System to Control the Post-surgery Osseointegration Process.Journal of biomedical physics & engineering · 2024Article
- Alkali-treated titanium dioxide promotes formation of proteoglycan layer and altered calcification and immunotolerance capacity in bone marrow stem cell.Biochemistry and biophysics reports · 2023Article
- Semaphorin 3A delivered by a rapidly polymerizing click hydrogel overcomes impaired implant osseointegration in a rat type 2 diabetes model.Acta biomaterialia · 2023Article
- Topography-mediated immunomodulation in osseointegration; Ally or Enemy.Biomaterials · 2022Review
- Canonical Wnt signaling enhances pro-inflammatory response to titanium by macrophages.Biomaterials · 2022Article
- Nanoscale hybrid implant surfaces and Osterix-mediated osseointegration.Journal of biomedical materials research. Part A · 2022Article
- Article
- Histological and Histomorphometric Comparison of Innovative Dental Implants Laser Obtained: Animal Pilot Study.Materials (Basel, Switzerland) · 2021Article
- Surface characteristics on commercial dental implants differentially activate macrophages in vitro and in vivo.Clinical oral implants research · 2021Article
- The effect of macrophages on an atmospheric pressure plasma-treated titanium membrane with bone marrow stem cells in a model of guided bone regeneration.Journal of materials science. Materials in medicine · 2020Article
- Microarc oxidation surface of titanium implants promote osteogenic differentiation by activating ERK1/2-miR-1827-Osterix.In vitro cellular & developmental biology. Animal · 2020Article
- Dental Implants with Different Neck Design: A Prospective Clinical Comparative Study with 2-Year Follow-Up.Materials (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Changes in dental implant materials, structural design, and surface properties can all affect biological response. While bulk properties are important for mechanical stability of the implant, surface design ultimately contributes to osseointegration. This article reviews the surface parameters of dental implant materials that contribute to improved cell response and osseointegration. In particular, we focus on how surface design affects mesenchymal cell response and differentiation into the osteoblast lineage. Surface roughness has been largely studied at the microscale, but recent studies have highlighted the importance of hierarchical micron/submicron/nanosurface roughness, as well as surface roughness in combination with surface wettability. Integrins are transmembrane receptors that recognize changes in the surface and mediate downstream signaling pathways. Specifically, the noncanonical Wnt5a pathway has been implicated in osteoblastic differentiation of cells on titanium implant surfaces. However, much remains to be elucidated. Only recently have studies been conducted on the differences in biological response to implants based on sex, age, and clinical factors; these all point toward differences that advocate for patient-specific implant design. Finally, challenges in implant surface characterization must be addressed to optimize and compare data across studies. An understanding of both the science and the biology of the materials is crucial for developing novel dental implant materials and surface modifications for improved osseointegration.
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Registered trials
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