Trial reportScientific reports2016
Triple-site rTMS for the treatment of chronic tinnitus: a randomized controlled trial.
Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01663324 (Repetitive Transcranial Magnetic Stimulation for the Treatment of Chronic Tinnitus), which is not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Repetitive Transcranial Magnetic Stimulation for the Treatment of Chronic Tinnitus: Optimization by Stimulation of the Cortical Tinnitus Network
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neuromodulation for Subjective Tinnitus: A Systematic Review and Meta-Analysis of Randomized Trials.The Laryngoscope · 2026Pooled it
- RTMS parameters in tinnitus trials: a systematic review.Scientific reports · 2019Pooled it
- Neuronavigated Versus Non-navigated Repetitive Transcranial Magnetic Stimulation for Chronic Tinnitus: A Randomized Study.Trends in hearingTrial
- Improvement of Chronic Tinnitus Following Personalized, Parcel-guided Accelerated rTMS: Feasibility in a Retrospective Case Series.Brain topography · 2025Article
- Activate & fire: a feasibility study in combining acoustic stimulation and continuous theta burst stimulation in chronic tinnitus.BMC neurology · 2023Article
- State of the art: non-invasive electrical stimulation for the treatment of chronic tinnitus.Therapeutic advances in chronic disease · 2023Review
- Long-Term Effects of Repetitive Transcranial Magnetic Stimulation on Tinnitus in a Guinea Pig Model.Brain sciences · 2022Article
- Personalization of Repetitive Transcranial Magnetic Stimulation for the Treatment of Chronic Subjective Tinnitus.Brain sciences · 2022Article
- Sequential Prefrontal and Temporoparietal Repetitive Transcranial Magnetic Stimulation (rTMS) for Treatment of Tinnitus With and Without Comorbid Depression: A Case Series and Systematic Review.Frontiers in neurology · 2022Article
- Implications of Transcranial Magnetic Stimulation as a Treatment Modality for Tinnitus.Journal of clinical medicine · 2021Review
- Heading for Personalized rTMS in Tinnitus: Reliability of Individualized Stimulation Protocols in Behavioral and Electrophysiological Responses.Journal of personalized medicine · 2021Article
- [Improving the role of rTMS and tDCS in the treatment of chronic tinnitus by combining other rehabilitation techniques].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021Review
- Methodological Aspects of Randomized Controlled Trials for Tinnitus: A Systematic Review and How a Decision Support System Could Overcome Barriers.Journal of clinical medicine · 2021Review
- Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers.Frontiers in aging neuroscience · 2021Review
- Association of Central Noninvasive Brain Stimulation Interventions With Efficacy and Safety in Tinnitus Management: A Meta-analysis.JAMA otolaryngology-- head & neck surgery · 2020Article
- Chronic tinnitus and the limbic system: Reappraising brain structural effects of distress and affective symptoms.NeuroImage. Clinical · 2019Article
- Review
- A Pilot Study of Peripheral Muscle Magnetic Stimulation as Add-on Treatment to Repetitive Transcranial Magnetic Stimulation in Chronic Tinnitus.Frontiers in neuroscience · 2018Article
- Individualized Repetitive Transcranial Magnetic Stimulation Treatment in Chronic Tinnitus?Frontiers in neurology · 2017Article
- Comparison of Amplitude Modulated Sounds and Pure Tones at the Tinnitus Frequency: Residual Tinnitus Suppression and Stimulus Evaluation.Trends in hearingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent research indicates that tinnitus is related to alterations of neural networks including temporal, parietal, and prefrontal brain regions. The current study examines a rTMS protocol which targets three central nodes of these networks in a two-arm randomized parallel group trial. Overall, 49 patients with chronic tinnitus were randomized to receive either triple-site stimulation (left dorsolateral prefrontal stimulation, 1000 pulses, 20 Hz plus left and right temporoparietal stimulation, 1000 pulses each, 1 Hz) or single-site stimulation (left temporoparietal stimulation, 3000 pulses, 1 Hz). Both groups were treated in ten sessions. Tinnitus severity as measured by the tinnitus questionnaire was assessed before rTMS (day1), after rTMS (day12) and at two follow-up visits (day 90 and day 180). The triple-site protocol was well tolerated. There was a significant reduction in tinnitus severity for both treatment groups. The triple-site group tended to show a more pronounced treatment effect at day 90. However, the measurement time point x group interaction effect was not significant. The current results confirm former studies that indicated a significant reduction of tinnitus severity after rTMS treatment. No significant superiority of the multisite protocol was observed. Future approaches for the enhancement of treatment effects are discussed.
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Registered trials
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