ArticleScientific reports2016
Sleep and mood disorders in dry eye disease and allied irritating ocular diseases.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Autologous serum eye drops for patients with dry eye disease: a systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2024Pooled it
- Dry eye disease and psychiatric disorders: A systematic review and meta-analysis.European journal of ophthalmology · 2022Pooled it
- A Prospective, Randomized Trial of Two Mucin Secretogogues for the Treatment of Dry Eye Syndrome in Office Workers.Scientific reports · 2017Trial
- AstroOphthalmology: ocular anterior segment.NPJ microgravity · 2026Review
- Immunomodulation of the Ocular Surface in Severe Dry Eye Disease: Expert-Driven Literature Review on Treatment Strategies with Description of Representative Challenging Cases.Ophthalmology and therapy · 2026Review
- Experience with ocular surface disease index analysis to assess dry eye disease and related conditions in Lagos, Nigeria.The Pan African medical journal · 2026Article
- Relationship Between Short Video Addiction Tendency and Depression Among Rural Older Adults: Cross-Sectional Study.Journal of medical Internet research · 2025Article
- Sleep quality and its determinants in patients with thyroid eye disease: a cross-sectional study.European journal of medical research · 2025Article
- Depression and Eye Disease-A Narrative Review of Common Underlying Pathophysiological Mechanisms and their Potential Applications.Journal of clinical medicine · 2024Review
- Associations between dry eye disease and sleep quality: a cross-sectional analysis.BMJ open ophthalmology · 2024Article
- Impaired sleep quality in children with allergic conjunctivitis and their parents.Eye (London, England) · 2023Article
- Evaluation and correlation analysis of ocular surface disorders and quality of life in autoimmune rheumatic diseases: a cross-sectional study.BMC ophthalmology · 2023Article
- Dry eye disease in astronauts: a narrative review.Frontiers in physiology · 2023Review
- Factors affecting the prevalence, severity, and characteristics of ocular surface pain.Expert review of ophthalmology · 2023Article
- Evaluation of the Regenerative Potential of Platelet-Lysate and Platelet-Poor Plasma Derived from the Cord Blood Units in Corneal Wound Healing Applications: An In Vitro Comparative Study on Corneal Epithelial Cells.Current issues in molecular biology · 2022Article
- Sleep disorders, mental health, and dry eye disease in South Korea.Scientific reports · 2022Article
- Sleep deprivation induces corneal epithelial progenitor cell over-expansion through disruption of redox homeostasis in the tear film.Stem cell reports · 2022Article
- A Review of Emerging Tear Proteomics Research on the Ocular Surface in Ocular Allergy.Biology · 2022Review
- The Association Between Dry Eye and Sleep Disorders: The Evidence and Possible Mechanisms.Nature and science of sleep · 2022Review
- Anxiety and depression in dry eye patients during the COVID-19 pandemic: Mental state investigation and influencing factor analysis.Frontiers in public health · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to evaluate sleep and mood disorders in patients with irritating ocular diseases. The study design was a cross-sectional/case-control study conducted in six eye clinics. Out of 715 outpatients diagnosed with irritating ocular surface diseases and initially enrolled, 301 patients with dry eye disease (DED) and 202 age-matched control participants with other ocular surface diseases were analyzed. The mean Pittsburgh Sleep Quality Index (PSQI) and Hospital Anxiety and Depression Scale (HADS) scores were 6.4 ± 3.2 and 11.1 ± 5.7 for severe DED (n = 146), 5.5 ± 3.3 and 9.8 ± 4.0 for mild DED (n = 155), 5.5 ± 3.1 and 9.5 ± 6.6 for chronic conjunctivitis (n = 124), and 5.0 ± 3.3 and 8.9 ± 5.3 for allergic conjunctivitis (n = 78). There were significant differences among these diagnostic groups for PSQI (P < 0.05). Regression analysis of patients with DED revealed the PSQI and HADS scores were significantly correlated with the severity of DED (P < 0.05). Our results demonstrate that sleep quality in patients with DED is significantly worse than in patients with other irritating ocular surface diseases and it is correlated with the severity of DED.
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