ReviewNeurocritical care2016
Moderate Traumatic Brain Injury: The Grey Zone of Neurotrauma.
Review in Neurocritical care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04900168 (A Multi-center Observational Cohort Study of Management of Moderate Traumatic Brain Injury With or Without Intracranial Pressure Monitoring in Patients With Moderate Traumatic Brain Injury in China), which is not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multi-center Observational Cohort Study of Management of Moderate Traumatic Brain Injury With or Without Intracranial Pressure Monitoring in Patients With Moderate Traumatic Brain Injury in China
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Comparing Region of Interest versus Voxel-Wise Diffusion Tensor Imaging Analytic Methods in Mild and Moderate Traumatic Brain Injury: A Systematic Review and Meta-Analysis.Journal of neurotrauma · 2019Pooled it
- Developing practical machine learning survival models to identify high-risk patients for in-hospital mortality following traumatic brain injury.Scientific reports · 2025Article
- Impact of interhospital transport on outcome in traumatic epidural hematoma: experiences of a level-1 trauma center.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Development and validation of a nomogram for predicting early neurological deterioration in patients with moderate traumatic brain injury: a retrospective analysis.Frontiers in neurology · 2025Article
- Resuscitation and Initial Management After Moderate-to-Severe Traumatic Brain Injury: Questions for the On-Call Shift.Journal of clinical medicine · 2024Review
- Quantitative Pupillometry for Intracranial Pressure (ICP) Monitoring in Traumatic Brain Injury: A Scoping Review.Neurocritical care · 2024Article
- Machine learning-based models to predict the need for neurosurgical intervention after moderate traumatic brain injury.Health science reports · 2023Article
- A multicenter observational study on outcomes of moderate and severe pediatric traumatic brain injuries-time to reappraise thresholds for treatment.Acta neurochirurgica · 2023Observational
- Influence of Sociodemographic, Premorbid, and Injury-Related Factors on Post-Traumatic Stress, Anxiety, and Depression after Traumatic Brain Injury.Journal of clinical medicine · 2023Article
- Predictors of outcomes in geriatric patients with moderate traumatic brain injury after ground level falls.Frontiers in medicine · 2023Article
- Intracranial-Pressure-Monitoring-Assisted Management Associated with Favorable Outcomes in Moderate Traumatic Brain Injury Patients with a GCS of 9-11.Journal of clinical medicine · 2022Article
- Pneumonia in Nervous System Injuries: An Analytic Review of Literature and Recommendations.Cureus · 2022Review
- "Can differences in hospitalised mild traumatic brain injury (mTBI) outcomes at 12 months be predicted?"Acta neurochirurgica · 2022Observational
- The effect of head cooling and remote ischemic conditioning on patients with traumatic brain injury.iScience · 2021Article
- White matter microstructure of the neural emotion regulation circuitry in mild traumatic brain injury.The European journal of neuroscience · 2021Article
- Emergency department management of traumatic brain injuries: A resource tiered review.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2020Review
- Latent Class Analysis to Classify Injury Severity in Pediatric Traumatic Brain Injury.Journal of neurotrauma · 2020Article
- Hemorrhage Associated Mechanisms of Neuroinflammation in Experimental Traumatic Brain Injury.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020Article
- Functional outcome is tied to dynamic brain states after mild to moderate traumatic brain injury.Human brain mapping · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Moderate traumatic brain injury (MTBI) is poorly defined in the literature and the nomenclature "moderate" is misleading, because up to 15 % of such patients may die. MTBI is a heterogeneous entity that shares many aspects of its pathophysiology and management with severe traumatic brain injury. Many patients who ''talk and died'' are MTBI. The role of neuroimaging is essential for the proper management of these patients. To analyze all aspects of the pathophysiology and management of MTBI, proposing a new way to categorize it considering the clinical picture and neuroimaging findings. We proposed a different approach to the group of patients with Glasgow Coma Scale (GCS) ranging from 9 through 13 and we discuss the rationale for this proposal. Patients with lower GCS scores (9-10), especially those with significant space-occupying lesions on the CT scan, should be managed following the guidelines for severe traumatic brain injury, with ICU observation, frequent serial computed tomography (CT) scanning and ICP monitoring. On the other hand, those with higher range GCS (11-13) can be managed more conservatively with serial neurological examination and CT scans. Given the available evidence, MTBI is an entity that needs reclassification. Large-scale and well-designed studies are urgently needed.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.