Evidence map›Paper›PMID 26927221›Full record

ArticleJournal of biomedical optics2016

Laser speckle imaging based on photothermally driven convection.

Caitlin Regan, Bernard Choi

Open access · bronzeAbstract read
In one paragraph

Article in Journal of biomedical optics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Visualization ofBiomedical optics express · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Caitlin ReganUniversity of California-Irvine, Department of Biomedical Engineering, 3120 Natural Sciences II, Irvine, California 92697, United StatesbBeckman Laser Institute and Medical Clinic, 1002 Health Sciences Road East, Irvine, California 92612, United States.
Bernard ChoiUniversity of California-Irvine, Department of Biomedical Engineering, 3120 Natural Sciences II, Irvine, California 92697, United StatesbBeckman Laser Institute and Medical Clinic, 1002 Health Sciences Road East, Irvine, California 92612, United StatescUn.
Beckman Laser Institute and Medical Clinic · USUniversity of California, Irvine · US

Funding

Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI DURKIN, ANTHONY · 2012 to 2017
$7.0M
Novel Optical Treatment Approach for Vascular BirthmarksR01HD065536 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHOI, BERNARD, KELLY, KRISTEN M · 2010 to 2014
$1.4M
Low-cost, noninvasive method to assess pulpal vitalityR01DE022831 · NIDCR · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHOI, BERNARD, WILDER-SMITH, PETRA E · 2013 to 2015
$1.0M
NIBIB NIH HHS P41 EB015890NICHD NIH HHS R01 HD065536NIDCR NIH HHS R01 DE022831
6 · The paper itself

Abstract

Laser speckle imaging (LSI) is an interferometric technique that provides information about the relative speed of moving scatterers in a sample. Photothermal LSI overcomes limitations in depth resolution faced by conventional LSI by incorporating an excitation pulse to target absorption by hemoglobin within the vascular network. Here we present results from experiments designed to determine the mechanism by which photothermal LSI decreases speckle contrast. We measured the impact of mechanical properties on speckle contrast, as well as the spatiotemporal temperature dynamics and bulk convective motion occurring during photothermal LSI. Our collective data strongly support the hypothesis that photothermal LSI achieves a transient reduction in speckle contrast due to bulk motion associated with thermally driven convection. The ability of photothermal LSI to image structures below a scattering medium may have important preclinical and clinical applications.

Indexed as

ConvectionLasersAnimalsBlood Physiological PhenomenaImage Processing, Computer-AssistedInterferometryPhantoms, ImagingRabbitsTemperatureTitaniumTitaniumtitanium dioxide

Identifiers

PMID26927221
PMCPMC4962529
OpenAlexW2284458241

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.