Evidence map›Paper›PMID 26927169›Full record

ArticleNutrients2016

Validation of Correction Algorithms for Near-IR Analysis of Human Milk in an Independent Sample Set-Effect of Pasteurization.

Gynter Kotrri, Gerhard Fusch, Celia Kwan, Dasol Choi, Arum Choi, Nisreen Al Kafi, Niels Rochow, Christoph Fusch

2 registry-linked trialsOpen access · goldAbstract readComparative StudyValidation Study
In one paragraph

Article in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01305642 nacompletednot on this map

Individualized Fortification of Breast Milk for Preterm Infants - A Pilot Study

TypeinterventionalSponsorMcMaster Children's HospitalRan2011 to 2011Enrolled13ConditionsPostnatal Growth DisorderArmsIndividualized fortification of breast milk
NCT02865941 naunknown statusnot on this map

Target Fortification of Breast Milk: The Effect of Different Schedules for Milk Analysis on the Growth and Development of Preterm Infants.

TypeinterventionalSponsorMcMaster Children's HospitalRan2016 to 2019Enrolled56ConditionsPostnatal Growth DisorderArmsFortification with modular protein, Fortification with modular carbohydrate, Fortification with modular fat
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Videoconferencing with the Hospitalized Premature Infant while Expressing Milk: A Randomized Crossover Trial.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2026
    Trial
  2. Article
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  9. Transmission infrared spectroscopy for rapid quantification of fat, protein, and lactose concentrations in human milk.Journal of perinatology : official journal of the California Perinatal Association · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Gynter KotrriDivision of Neonatology, Department of Pediatrics, McMaster University, 1280 Main Street West, Room HSC-4F5, Hamilton, ON L8S 4K1, Canada. gynter1994@hotmail.com.
Gerhard FuschDivision of Neonatology, Department of Pediatrics, McMaster University, 1280 Main Street West, Room HSC-4F5, Hamilton, ON L8S 4K1, Canada. gefusch@mcmaster.ca.
Celia KwanDivision of Neonatology, Department of Pediatrics, McMaster University, 1280 Main Street West, Room HSC-4F5, Hamilton, ON L8S 4K1, Canada. kwanc4@mcmaster.ca.
Dasol ChoiDivision of Neonatology, Department of Pediatrics, McMaster University, 1280 Main Street West, Room HSC-4F5, Hamilton, ON L8S 4K1, Canada. choi7453@naver.com.
Arum ChoiDivision of Neonatology, Department of Pediatrics, McMaster University, 1280 Main Street West, Room HSC-4F5, Hamilton, ON L8S 4K1, Canada. choiar@mcmaster.ca.
Nisreen Al KafiDivision of Neonatology, Department of Pediatrics, McMaster University, 1280 Main Street West, Room HSC-4F5, Hamilton, ON L8S 4K1, Canada. nkafi@yahoo.com.
Niels RochowDivision of Neonatology, Department of Pediatrics, McMaster University, 1280 Main Street West, Room HSC-4F5, Hamilton, ON L8S 4K1, Canada. nielsrochow@gmail.com.
Christoph FuschDivision of Neonatology, Department of Pediatrics, McMaster University, 1280 Main Street West, Room HSC-4F5, Hamilton, ON L8S 4K1, Canada. fusch@mcmaster.ca.
McMaster University · CA

Funding

Canadian Institutes of Health Research MOP-125883
6 · The paper itself

Abstract

Commercial infrared (IR) milk analyzers are being increasingly used in research settings for the macronutrient measurement of breast milk (BM) prior to its target fortification. These devices, however, may not provide reliable measurement if not properly calibrated. In the current study, we tested a correction algorithm for a Near-IR milk analyzer (Unity SpectraStar, Brookfield, CT, USA) for fat and protein measurements, and examined the effect of pasteurization on the IR matrix and the stability of fat, protein, and lactose. Measurement values generated through Near-IR analysis were compared against those obtained through chemical reference methods to test the correction algorithm for the Near-IR milk analyzer. Macronutrient levels were compared between unpasteurized and pasteurized milk samples to determine the effect of pasteurization on macronutrient stability. The correction algorithm generated for our device was found to be valid for unpasteurized and pasteurized BM. Pasteurization had no effect on the macronutrient levels and the IR matrix of BM. These results show that fat and protein content can be accurately measured and monitored for unpasteurized and pasteurized BM. Of additional importance is the implication that donated human milk, generally low in protein content, has the potential to be target fortified.

Indexed as

AlgorithmsPasteurizationFemaleHumansLactoseLipidsMilk, HumanMilk ProteinsNutritive ValueProspective StudiesProtein DenaturationProtein StabilityReproducibility of ResultsSpectroscopy, Near-InfraredLactoseLipidsMilk Proteinsanalyzerdonor milkfatlactosemilknutritionpretermproteinterm

Identifiers

PMID26927169
PMCPMC4808849
OpenAlexW2286192392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.