ArticleInternational journal of molecular sciences2016
Immunohistochemical Analysis of Cerebral Thrombi Retrieved by Mechanical Thrombectomy from Patients with Acute Ischemic Stroke.
Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Correlation of imaging and histopathology of thrombi in acute ischemic stroke with etiology and outcome: a systematic review.Journal of neurointerventional surgery · 2017Pooled it
- NLRP3 Marks an Inflammatory Neutrophil-NETosis-Pyroptosis Network in Human Ischemic Stroke Thrombi.Cells · 2026Article
- Different Long-Term Outcomes According to Thrombus Histology in Patients With Acute Ischemic Stroke.Journal of stroke · 2026Article
- Thrombi from stroke due to cardioembolic etiology have higher CD11b-positive cells compared to large artery atherosclerosis.Journal of thrombosis and thrombolysis · 2026Article
- Is There a Relationship Between the Histopathological Features and Anatomical Locations of Thrombi Obtained During Endovascular Thrombectomy in Acute Ischemic Stroke and Its Comorbid Diseases?Diagnostics (Basel, Switzerland) · 2025Article
- Clot Composition and Ischemic Stroke Etiology: A Contemporary Narrative Review.Journal of clinical medicine · 2025Review
- Resolution of Ascending Aorta and Pulmonary Vein Thrombi With Apixaban Therapy: A Case Study.Cureus · 2025Article
- Thrombo-CARE-cardioembolic stroke etiology in cryptogenic stroke suggested by fibrin-/platelet-rich clot histology : Thrombo-CARE (configuration analysis to refine etiology).Wiener medizinische Wochenschrift (1946) · 2025Article
- Thrombus perviousness in acute ischemic stroke: a scoping review of methodology, predictive value, and future perspectives.Neuroradiology · 2025Article
- Platelet Analysis in the Thrombus Plus Serum BNP for Detecting Clot-Related Atrial Fibrillation. Results From the ITACAT Multicentric Registry.Translational stroke research · 2025Article
- Thrombus composition and distribution patterns by thrombus volume in acute ischemic stroke.Frontiers in neurology · 2025Article
- Is Clot Composition Associated With Cause of Stroke? A Systematic Review and Meta-Analysis.Stroke (Hoboken, N.J.) · 2024Article
- Gene expression profiles of ischemic stroke clots retrieved by mechanical thrombectomy are associated with disease etiology.Journal of neurointerventional surgery · 2023Article
- Association between thrombus composition and stroke etiology in the MR CLEAN Registry biobank.Neuroradiology · 2023Article
- Advancing Stroke Research on Cerebral Thrombi with Omic Technologies.International journal of molecular sciences · 2023Review
- Short-term efficacy of stenting as a rescue therapy for acute atherosclerotic occlusion in anterior cerebral circulation.Frontiers in neurology · 2023Article
- Is Composition of Brain Clot Retrieved by Mechanical Thrombectomy Associated with Stroke Aetiology and Clinical Outcomes in Acute Ischemic Stroke?-A Systematic Review and Meta-Analysis.Neurology international · 2022Article
- Automated Composition Analysis of Thrombus from Endovascular Treatment in Acute Ischemic Stroke Using Computer Vision.Journal of stroke · 2022Article
- Structure of shear-induced platelet aggregated clot formed in an in vitro arterial thrombosis model.Blood advances · 2022Article
- Prognostic Signature for Human Umbilical Cord Mesenchymal Stem Cell Treatment of Ischemic Cerebral Infarction by Integrated Bioinformatic Analysis.BioMed research international · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanical thrombectomy is a novel treatment option for patients with acute ischemic stroke (AIS). Only a few studies have previously suggested strategies to categorize retrieved clots according to their histologic composition. However, these reports did not analyze potential biomarkers that are of importance in stroke-related inflammation. We therefore histopathologically investigated 37 intracerebral thrombi mechanically retrieved from patients with AIS, and focused on the composition of immune cells and platelets. We also conducted correlation analyses of distinctive morphologic patterns (erythrocytic, serpentine, layered, red, white, mixed appearance) with clinical parameters. Most T cells and monocytes were detected in erythrocytic and red clots, in which the distribution of these cells was random. In contrast, von Willebrand factor (vWF)-positive areas co-localized with regions of fibrin and collagen. While clots with huge amounts of vWF seem to be associated with a high National Institute of Health Stroke Scale score at admission, histologic findings could not predict the clinical outcome at discharge. In summary, we provide the first histologic description of mechanically retrieved intracerebral thrombi regarding biomarkers relevant for inflammation in ischemic stroke.
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