ArticleInternational journal of molecular sciences2016
Silicon-Doped Titanium Dioxide Nanotubes Promoted Bone Formation on Titanium Implants.
Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 58 citations in OpenAlex.
- In Situ Tantalum Doping of Titanium Dioxide Nanotubes via Electrochemical Method for Enhanced Mechanical and Biological Properties.Journal of functional biomaterials · 2026Article
- Effect of Silicon Carbide Coating on Osteoblast Mineralization of Anodized Titanium Surfaces.Journal of functional biomaterials · 2022Article
- Engineering immunomodulatory and osteoinductive implant surfaces via mussel adhesion-mediated ion coordination and molecular clicking.Nature communications · 2022Article
- Antibacterial quaternary ammonium chitosan/carboxymethyl starch/alginate sponges with enhanced hemostatic property for the prevention of dry socket.Frontiers in bioengineering and biotechnology · 2022Article
- Histologic and Histomorphometric Evaluation of a New Bioactive Liquid BBL on Implant Surface: A Preclinical Study in Foxhound Dogs.Materials (Basel, Switzerland) · 2021Article
- Nanostructured Surfaces to Promote Osteoblast Proliferation and Minimize Bacterial Adhesion on Titanium.Materials (Basel, Switzerland) · 2021Article
- Titanium dioxide nanotubes as drug carriers for infection control and osteogenesis of bone implants.Drug delivery and translational research · 2021Review
- Evolution of anodised titanium for implant applications.Heliyon · 2021Review
- Prospect of Metal Ceramic (Titanium-Wollastonite) Composite as Permanent Bone Implants: A Narrative Review.Materials (Basel, Switzerland) · 2021Review
- Exploring Macroporosity of Additively Manufactured Titanium Metamaterials for Bone Regeneration with Quality by Design: A Systematic Literature Review.Materials (Basel, Switzerland) · 2020Review
- Enhanced Osseointegration of Titanium Implants by Surface Modification with Silicon-doped Titania Nanotubes.International journal of nanomedicine · 2020Article
- Zn-Incorporated TiOInternational journal of nanomedicine · 2020Article
- Dual Doping of Silicon and Manganese in Hydroxyapatites: Physicochemical Properties and Preliminary Biological Studies.Materials (Basel, Switzerland) · 2019Article
- Immobilization of Denosumab on Titanium Affects Osteoclastogenesis of Human Peripheral Blood Monocytes.International journal of molecular sciences · 2019Article
- Surface Immobilization of TiOBioMed research international · 2019Article
- Improved osseointegration properties of hierarchical microtopographic/nanotopographic coatings fabricated on titanium implants.International journal of nanomedicine · 2018Article
- Biofunctional Sr- and Si-loaded titania nanotube coating of Ti surfaces by anodization-hydrothermal process.International journal of nanomedicine · 2018Article
- Bio-Functional Design, Application and Trends in Metallic Biomaterials.International journal of molecular sciences · 2017Review
- Antimicrobial and Osseointegration Properties of Nanostructured Titanium Orthopaedic Implants.Materials (Basel, Switzerland) · 2017Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While titanium (Ti) implants have been extensively used in orthopaedic and dental applications, the intrinsic bioinertness of untreated Ti surface usually results in insufficient osseointegration irrespective of the excellent biocompatibility and mechanical properties of it. In this study, we prepared surface modified Ti substrates in which silicon (Si) was doped into the titanium dioxide (TiO₂) nanotubes on Ti surface using plasma immersion ion implantation (PIII) technology. Compared to TiO₂ nanotubes and Ti alone, Si-doped TiO₂ nanotubes significantly enhanced the expression of genes related to osteogenic differentiation, including Col-I, ALP, Runx2, OCN, and OPN, in mouse pre-osteoblastic MC3T3-E1 cells and deposition of mineral matrix. In vivo, the pull-out mechanical tests after two weeks of implantation in rat femur showed that Si-doped TiO₂ nanotubes improved implant fixation strength by 18% and 54% compared to TiO₂-NT and Ti implants, respectively. Together, findings from this study indicate that Si-doped TiO₂ nanotubes promoted the osteogenic differentiation of osteoblastic cells and improved bone-Ti integration. Therefore, they may have considerable potential for the bioactive surface modification of Ti implants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.