ReviewInternational journal of molecular sciences2016
Xylose Fermentation by Saccharomyces cerevisiae: Challenges and Prospects.
Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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Who cites it
80 citing papers in PubMed.
- AmXlnR, a transcription factor involved in xylan degradation and pentose catabolism, enhances pullulan production from xylose inSynthetic and systems biotechnology · 2026Article
- Systems-Level Metabolic Regulation Strategies of Xylose Metabolism in Saccharomyces cerevisiae.Biotechnology journal · 2026Review
- Biotechnological applications of D-xylose-fermenting autochthonous yeasts in lignocellulosic biorefineries.Biotechnology for biofuels and bioproducts · 2026Review
- Diversity of Yeast and Drosophila Species Associated with Grape Sour Rot in China.Microbial ecology · 2025Article
- Identifying promoters to enhance heterologous gene expression in recombinant Saccharomyces cerevisiae strains cultivated on non-native substrates.Applied microbiology and biotechnology · 2025Article
- Enhanced Sugar and Bioethanol Production from Broom Grass via NaOH-Autoclave Pretreatment.Polymers · 2025Article
- Biofuel production from lignocellulose via thermophile-based consolidated bioprocessing.Engineering microbiology · 2024Review
- Assessing Process Conditions on Xylose Fermentation in Spathaspora passalidarum: Effects of pH, Substrate-to-Inoculum Ratio, Temperature, and Initial Ethanol Concentration.Current microbiology · 2024Article
- Construction of an alternative NADPH regeneration pathway improves ethanol production inSynthetic and systems biotechnology · 2024Article
- Agricultural Waste Management by Production of Second-Generation Bioethanol from Sugarcane Bagasse Using Indigenous Yeast Strain.Current microbiology · 2024Article
- Evaluation of Pyrophosphate-Driven Proton Pumps inMicroorganisms · 2024Article
- Engineering Saccharomyces cerevisiae for targeted hydrolysis and fermentation of glucuronoxylan through CRISPR/Cas9 genome editing.Microbial cell factories · 2024Article
- Oxygenation influences xylose fermentation and gene expression in the yeast genera Spathaspora and Scheffersomyces.Biotechnology for biofuels and bioproducts · 2024Article
- Characterization of pectinase-producing Saccharomyces cerevisiae UCDFST 09-448 and its effects on cull peach fermentations.Journal of industrial microbiology & biotechnology · 2024Article
- Review
- Fermentative processes for the upcycling of xylose to xylitol by immobilized cells ofFrontiers in bioengineering and biotechnology · 2024Article
- Impact of xylose epimerase on sugar assimilation and sensing in recombinant Saccharomyces cerevisiae carrying different xylose-utilization pathways.Biotechnology for biofuels and bioproducts · 2023Article
- Evaluation of Preparation and Detoxification of Hemicellulose Hydrolysate for Improved Xylitol Production from Quinoa Straw.International journal of molecular sciences · 2022Article
- A Listeria ivanovii balanced-lethal system may be a promising antigen carrier for vaccine construction.Microbial biotechnology · 2022Article
- Engineering the xylose metabolism in Schizochytrium sp. to improve the utilization of lignocellulose.Biotechnology for biofuels and bioproducts · 2022Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many years have passed since the first genetically modified Saccharomyces cerevisiae strains capable of fermenting xylose were obtained with the promise of an environmentally sustainable solution for the conversion of the abundant lignocellulosic biomass to ethanol. Several challenges emerged from these first experiences, most of them related to solving redox imbalances, discovering new pathways for xylose utilization, modulation of the expression of genes of the non-oxidative pentose phosphate pathway, and reduction of xylitol formation. Strategies on evolutionary engineering were used to improve fermentation kinetics, but the resulting strains were still far from industrial application. Lignocellulosic hydrolysates proved to have different inhibitors derived from lignin and sugar degradation, along with significant amounts of acetic acid, intrinsically related with biomass deconstruction. This, associated with pH, temperature, high ethanol, and other stress fluctuations presented on large scale fermentations led the search for yeasts with more robust backgrounds, like industrial strains, as engineering targets. Some promising yeasts were obtained both from studies of stress tolerance genes and adaptation on hydrolysates. Since fermentation times on mixed-substrate hydrolysates were still not cost-effective, the more selective search for new or engineered sugar transporters for xylose are still the focus of many recent studies. These challenges, as well as under-appreciated process strategies, will be discussed in this review.
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