ArticleBMC plant biology2016
Population genetic analysis of a medicinally significant Australian rainforest tree, Fontainea picrosperma C.T. White (Euphorbiaceae): biogeographic patterns and implications for species domestication and plantation establishment.
Article in BMC plant biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- An Engineered Heat-Inducible Expression System for the Production of Casbene inInternational journal of molecular sciences · 2023Article
- Floral attraction and flower visitors of a subcanopy, tropical rainforest tree,Ecology and evolution · 2021Article
- Developing a Nicotiana benthamiana transgenic platform for high-value diterpene production and candidate gene evaluation.Plant biotechnology journal · 2021Article
- Conservation concerns associated with low genetic diversity for K'gari-Fraser Island dingoes.Scientific reports · 2021Article
- The P450 multigene family of Fontainea and insights into diterpenoid synthesis.BMC plant biology · 2021Article
- Article
- A multidisciplinary approach to inform assisted migration of the restricted rainforest tree, Fontainea rostrata.PloS one · 2019Article
- Conservation choice on the rare endangered plantsConservation physiology · 2018Article
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4 authors.
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Abstract
backgroundFontainea picrosperma, a subcanopy tree endemic to the rainforests of northeastern Australia, is of medicinal significance following the discovery of the novel anti-cancer natural product, EBC-46. Laboratory synthesis of EBC-46 is unlikely to be commercially feasible and consequently production of the molecule is via isolation from F. picrosperma grown in plantations. Successful domestication and plantation production requires an intimate knowledge of a taxon's life-history attributes and genetic architecture, not only to ensure the maximum capture of genetic diversity from wild source populations, but also to minimise the risk of a detrimental loss in genetic diversity via founder effects during subsequent breeding programs designed to enhance commercially significant agronomic traits.
resultsHere we report the use of eleven microsatellite loci (PIC = 0.429; P ID = 1.72 × 10(-6)) to investigate the partitioning of genetic diversity within and among seven natural populations of F. picrosperma. Genetic variation among individuals and within populations was found to be relatively low (A = 2.831; H E = 0.407), although there was marked differentiation among populations (PhiPT = 0.248). Bayesian, UPGMA and principal coordinates analyses detected three main genotypic clusters (K = 3), which were present at all seven populations. Despite low levels of historical gene flow (N m = 1.382), inbreeding was negligible (F = -0.003); presumably due to the taxon's dioecious breeding system.
conclusionThe data suggests that F. picrosperma was previously more continuously distributed, but that rainforest contraction and expansion in response to glacial-interglacial cycles, together with significant anthropogenic effects have resulted in significant fragmentation. This research provides important tools to support plantation establishment, selection and genetic improvement of this medicinally significant Australian rainforest species.
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