ArticleScientific reports2016
Obesity impairs lactation performance in mice by inducing prolactin resistance.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Incidence and factors influencing delayed onset of lactation: a systematic review and meta-analysis.International breastfeeding journal · 2024Pooled it
- Effectiveness of a new breastfeeding counselling intervention on breastfeeding prevalence, infant growth velocity and postpartum weight loss in overweight women: a randomized controlled trial.International breastfeeding journal · 2025Trial
- Maternal Adiposity, Milk Production and Removal, and Infant Milk Intake During Established Lactation.Nutrients · 2025Article
- Maternal Factors, Breast Anatomy, and Milk Production During Established Lactation-An Ultrasound Investigation.Journal of imaging · 2025Article
- Prenatal maternal HFD exposure impairs cognition via a hippocampal NMDA mechanism.Translational psychiatry · 2025Article
- Etiology of Delayed Lactogenesis in Obesity.Biomedicines · 2025Review
- Milk Composition Is Predictive of Low Milk Supply Using Machine Learning Approaches.Diagnostics (Basel, Switzerland) · 2025Article
- Review
- Placenta-derived SOD3 deletion impairs maternal behavior via alterations in FGF/FGFR-prolactin signaling axis.Cell reports · 2024Article
- The Impact of Maternal Obesity on Adipose Progenitor Cells.Biomedicines · 2023Review
- Article
- Programming of metabolism by adipokines during development.Nature reviews. Endocrinology · 2023Review
- The contributions of parental lactation on offspring development: It's not udder nonsense!Hormones and behavior · 2023Review
- Parental factors that impact the ecology of human mammary development, milk secretion, and milk composition-a report from "Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN)" Working Group 1.The American journal of clinical nutrition · 2023Article
- Protocol for an observational study investigating hormones triggering the onset of sustained lactation: the INSIGHT study.BMJ open · 2022Article
- Article
- Lactational Amenorrhea: Neuroendocrine Pathways Controlling Fertility and Bone Turnover.International journal of molecular sciences · 2022Review
- Human Milk Glucose, Leptin, and Insulin Predict Cessation of Full Breastfeeding and Initiation of Formula Use.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2021Article
- The Prolactin Family of Hormones as Regulators of Maternal Mood and Behavior.Frontiers in global women's health · 2021Review
- Breastfeeding Practices and Problems Among Obese Women Compared with Nonobese Women in a Brazilian Hospital.Women's health reports (New Rochelle, N.Y.) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity reduces breastfeeding success and lactation performance in women. However, the mechanisms involved are not entirely understood. In the present study, female C57BL/6 mice were chronically exposed to a high-fat diet to induce obesity and subsequently exhibited impaired offspring viability (only 15% survival rate), milk production (33% reduction), mammopoiesis (one-third of the glandular area compared to control animals) and postpartum maternal behaviors (higher latency to retrieving and grouping the pups). Reproductive experience attenuated these defects. Diet-induced obese mice exhibited high basal pSTAT5 levels in the mammary tissue and hypothalamus, and an acute prolactin stimulus was unable to further increase pSTAT5 levels above basal levels. In contrast, genetically obese leptin-deficient females showed normal prolactin responsiveness. Additionally, we identified the expression of leptin receptors specifically in basal/myoepithelial cells of the mouse mammary gland. Finally, high-fat diet females exhibited altered mRNA levels of ERBB4 and NRG1, suggesting that obesity may involve disturbances to mammary gland paracrine circuits that are critical in the control of luminal progenitor function and lactation. In summary, our findings indicate that high leptin levels are a possible cause of the peripheral and central prolactin resistance observed in obese mice which leads to impaired lactation performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.