ArticleEnvironmental health : a global access science source2016
Longitudinal associations of age and prenatal lead exposure on cortisol secretion of 12-24 month-old infants from Mexico City.
Article in Environmental health : a global access science source, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Lead exposure, glucocorticoids, and physiological stress across the life course: A systematic review.Environmental pollution (Barking, Essex : 1987) · 2024Pooled it
- Prenatal exposure to metal(loid)s mixture and childhood lung function: Exploring sex-specific associations.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Associations between prenatal metal mixtures and allergic symptoms in childhood.The Science of the total environment · 2025Article
- Do not exclude your observations: Negative cortisol awakening responses (CAR) may be biologically relevant.Psychoneuroendocrinology · 2025Article
- Prenatal metal exposures and childhood gut microbial signatures are associated with depression score in late childhood.The Science of the total environment · 2024Article
- Associations of prenatal and childhood Pb exposure with allostatic load in adolescence: Findings from the ELEMENT cohort study.Environmental research · 2023Article
- Association between prenatal metal exposure and adverse respiratory symptoms in childhood.Environmental research · 2022Article
- Prenatal metal mixture concentrations and reward motivation in children.Neurotoxicology · 2022Article
- Predictors of patterns of weight change 1 year after delivery in a cohort of Mexican women.Public health nutrition · 2021Article
- Cell-Based Bioassay to Screen Environmental Chemicals and Human Serum for Total Glucocorticogenic Activity.Environmental toxicology and chemistry · 2021Article
- Combined Impacts of Prenatal Environmental Exposures and Psychosocial Stress on Offspring Health: Air Pollution and Metals.Current environmental health reports · 2020Review
- Patterns of Weight Change One Year after Delivery Are Associated with Cardiometabolic Risk Factors at Six Years Postpartum in Mexican Women.Nutrients · 2020Article
- Is prenatal arsenic exposure associated with salivary cortisol in infants in Arica, Chile? An exploratory cohort study.Annals of agricultural and environmental medicine : AAEM · 2019Article
- Diurnal Cortisol Concentrations and Growth Indexes of 12- to 48-Month-Old Children From Mexico City.The Journal of clinical endocrinology and metabolism · 2018Article
- Prenatal manganese exposure and intrinsic functional connectivity of emotional brain areas in children.Neurotoxicology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundCortisol has functions on homeostasis, growth, neurodevelopment, immune function and the stress response. Secretion follows a diurnal rhythm that mediates these processes. Our objective was to examine the association between prenatal lead exposure and infant diurnal cortisol rhythms.
methodsWe measured infant cortisol rhythms in saliva collected repeatedly over 2 days at either 12 (n = 255) or 18-24 (n = 150) months of age. Prenatal lead exposure was assessed by measuring maternal pregnancy blood lead levels and early postnatal maternal bone lead content. We analyzed age-specific basal secretion and the association between trimester-specific and cumulative lead exposure with a) change in total diurnal cortisol and b) the shape of the cortisol curve across the length of the day.
resultsOur results showed age related differences in salivary cortisol secretion and an age dependent association with maternal lead exposure. In age-stratified models we saw an inverse association between lead and cortisol levels in 12-month-old infants and a positive association for 18-24-month-old infants. For the 12-month-old infants 2nd-trimester-lead ≥10 μg/dL was associated with 40 % lower cortisol levels (95 % CI (-57, -16)) and a significant change in the shape of the cortisol curve (p = 0.01), compared to infants with low blood lead levels (<5 μg/dL).
conclusionsBasal cortisol secretion changes with age. Increased early gestation lead exposure alters diurnal cortisol rhythms and the association is modified by infant age, perhaps representing an early maturation of cortisol homeostasis.
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