ArticleAntimicrobial agents and chemotherapy2016
In Vitro Approach for Identification of the Most Effective Agents for Antimicrobial Lock Therapy in the Treatment of Intravascular Catheter-Related Infections Caused by Staphylococcus aureus.
Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Not All Antiseptic Solutions Are Equivalent in Removing Biofilm: A Comparison Across Different Orthopaedic Surfaces.The Journal of bone and joint surgery. American volume · 2025Article
- Potent antimicrobial activity of hydrogel loaded with the antimicrobial peptide, D-Bac8cFrontiers in microbiology · 2025Article
- Usefulness of daptomycin lock therapy in children with catheter-related bacteremia after failed vancomycin lock therapy.Annals of clinical microbiology and antimicrobials · 2023Article
- Antimicrobial Treatment ofAntibiotics (Basel, Switzerland) · 2023Review
- Assuring the Biofunctionalization of Silicone Covalently Bonded to Rhamnolipids: Antibiofilm Activity and Biocompatibility.Pharmaceutics · 2022Article
- The crafty opponent: the defense systems of Staphylococcus aureus and response measures.Folia microbiologica · 2022Review
- Topical Antibiofilm Agents With Potential Utility in the Treatment of Chronic Rhinosinusitis: A Narrative Review.Frontiers in pharmacology · 2022Review
- Review
- Review
- Long-term stability of gentamicin sulfate-ethylenediaminetetraacetic acid disodium salt (EDTA-NaJournal of pharmaceutical analysis · 2018Article
- Article
- Targeting the Bacterial Protective Armour; Challenges and Novel Strategies in the Treatment of Microbial Biofilm.Materials (Basel, Switzerland) · 2018Review
- Novel Treatment of Staphylococcus aureus Device-Related Infections Using Fibrinolytic Agents.Antimicrobial agents and chemotherapy · 2018Article
- Differential Activity of the Combination of Vancomycin and Amikacin on Planktonic vs. Biofilm-GrowingFrontiers in microbiology · 2018Article
- 5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus.The Journal of antimicrobial chemotherapy · 2017Article
- Comparative Efficacies of Antimicrobial Catheter Lock Solutions for Fungal Biofilm Eradication in an in Vitro Model of Catheter-Related Fungemia.Journal of fungi (Basel, Switzerland) · 2017Article
- Convergence of Staphylococcus aureus Persister and Biofilm Research: Can Biofilms Be Defined as Communities of Adherent Persister Cells?PLoS pathogens · 2016Review
- Eradication of Staphylococcus aureus Catheter-Related Biofilm Infections Using ML:8 and Citrox.Antimicrobial agents and chemotherapy · 2016Article
- Untangling the Diverse and Redundant Mechanisms of Staphylococcus aureus Biofilm Formation.PLoS pathogens · 2016Review
- A comparison of catheter lock solutions and associated complications in pediatric intestinal failure patients.Intestinal Failure (New York, N.Y.)Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infection of intravascular catheters by Staphylococcus aureus is a significant risk factor within the health care setting. To treat these infections and attempt salvage of an intravascular catheter, antimicrobial lock solutions (ALSs) are being increasingly used. However, the most effective ALSs against these biofilm-mediated infections have yet to be determined, and clinical practice varies greatly. The purpose of this study was to evaluate and compare the efficacies of antibiotics and antiseptics in current clinical use against biofilms produced by reference and clinical isolates of S. aureus Static and flow biofilm assays were developed using newly described in vivo-relevant conditions to examine the effect of each agent on S. aureus within the biofilm matrix. The antibiotics daptomycin, tigecycline, and rifampin and the antiseptics ethanol and Taurolock inactivated established S. aureus biofilms, while other commonly used antistaphylococcal antibiotics and antiseptic agents were less effective. These findings were confirmed by live/dead staining of S. aureus biofilms formed and treated within a flow cell model. The results from this study demonstrate the most effective clinically used agents and their concentrations which should be used within an ALS to treat S. aureus-mediated intravascular catheter-related infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.