Trial reportNutrition & diabetes2016
Weight loss is associated with plasma free amino acid alterations in subjects with metabolic syndrome.
Trial report in Nutrition & diabetes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Amino acid composition of plant protein-enriched wheat biscuits differentially affects postprandial amino acid responses of overweight/obese compared to normalweight subjects.European journal of nutrition · 2025Trial
- The serum amino acid profile in COVID-19.Amino acids · 2021Trial
- The Efficacy of Short-Term Weight Loss Programs and Consumption of Natural Probiotic Bryndza Cheese on Gut Microbiota Composition in Women.Nutrients · 2021Trial
- Multicenter evaluation of prognostic nutritional index and systemic immune-inflammation index in predicting mortality among critically ill cardiovascular and cerebrovascular patients with varied glucose metabolism: a machine learning-based cohort study.Frontiers in nutrition · 2026Article
- Metabolite, Biochemical, and Dietary Intake Alterations Associated with Lifestyle Interventions in Obese and Overweight Malaysian Women.Nutrients · 2024Article
- Machine Learning-Based Plasma Metabolomics in Liraglutide-Treated Type 2 Diabetes Mellitus Patients and Diet-Induced Obese Mice.Metabolites · 2024Article
- Article
- Article
- Nutrients, Physical Activity, and Mitochondrial Dysfunction in the Setting of Metabolic Syndrome.Nutrients · 2023Review
- A Metabolomic Analysis of the Sex-Dependent Hispanic Paradox.Metabolites · 2021Article
- Article
- The effect of eight-week walking program on plasma levels of amino acids in early/mid pubertal obese girls.Medical journal of the Islamic Republic of Iran · 2019Article
- Development of Biomarkers for Inhibition of SLC6A19 (B⁰AT1)-A Potential Target to Treat Metabolic Disorders.International journal of molecular sciences · 2018Article
- Metabolite profiling of obese individuals before and after a one year weight loss program.International journal of obesity (2005) · 2017Observational
- Central adiposity-induced plasma-free amino acid alterations are associated with increased insulin resistance in healthy Singaporean adults.European journal of clinical nutrition · 2017Article
- Alteration in plasma free amino acid levels and its association with gout.Environmental health and preventive medicine · 2017Article
- Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss.International journal of endocrinology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe prevalence of metabolic syndrome is increasing worldwide, especially in Asian populations. Early detection and effective intervention are vital. Plasma free amino acid profile is a potential biomarker for the early detection for lifestyle-related diseases. However, little is known about whether the altered plasma free amino acid profiles in subjects with metabolic syndrome are related to the effectiveness of dietary and exercise interventions.
methodsEighty-five Japanese subjects who fulfilled the Japanese diagnostic criteria for metabolic syndrome were enrolled in a 3-month diet and exercise intervention. The plasma free amino acid concentrations and metabolic variables were measured, and the relationships between plasma free amino acid profiles, metabolic variables and the extent of body weight reduction were investigated. Those who lost more than 3% of body weight were compared with those who lost less than 3%.
resultsBaseline levels of most amino acids in the subset that went on to lose <3% body weight were markedly lower compared with the counterpart, although both groups showed similar proportional pattern of plasma amino acid profiles. The weight loss induced by the diet and exercise intervention normalized plasma free amino acid profiles. For those with a high degree of weight loss, those changes were also associated with improvement in blood pressure, triglyceride and hemoglobin A1c levels.
conclusionsThese data suggest that among Japanese adults meeting the criteria for metabolic syndrome, baseline plasma free amino acid profiles may differ in ways that predict who will be more vs less beneficially responsive to a standard diet and exercise program. Plasma free amino acid profiles may also be useful as markers for monitoring the risks of developing lifestyle-related diseases and measuring improvement in physiological states.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.