ArticleNeuropsychologia2016
Interactive effects of age and multi-gene profile on motor learning and sensorimotor adaptation.
Article in Neuropsychologia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- The effect of dopamine D2-like receptor blockade on human motor performance and skill acquisition.Scientific reports · 2026Trial
- Genetic Variation in the Dopamine System Influences Intervention Outcome in Children with Cerebral Palsy.EBioMedicine · 2018Trial
- Visuomotor adaptation across the lifespan.PloS one · 2024Article
- Catechol-O-methyltransferase (COMT) polymorphism predicts rapid gait speed changes in healthy older adults.Journal of the American Geriatrics Society · 2021Article
- Genetic variation in dopamine neurotransmission and motor development of infants born extremely-low-birthweight.Developmental medicine and child neurology · 2020Article
- Influence of Striatal Dopamine, Cerebral Small Vessel Disease, and Other Risk Factors on Age-Related Parkinsonian Motor Signs.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- The effect of age on visuomotor learning processes.PloS one · 2020Article
- Article
- Genetic markers of dopaminergic transmission predict performance for older males but not females.Neurobiology of aging · 2018Article
- The relationship between BDNF Val66Met polymorphism and functional mobility in chronic stroke survivors.Topics in stroke rehabilitation · 2018Article
- Dopaminergic polymorphisms associated with medication responsiveness of gait in Parkinson's disease.Parkinsonism & related disorders · 2018Article
- Sensorimotor Learning: Neurocognitive Mechanisms and Individual Differences.Journal of neuroengineering and rehabilitation · 2017Review
- Physical Therapy for Neurological Conditions in Geriatric Populations.Frontiers in public health · 2017Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The interactive association of age and dopaminergic polymorphisms on cognitive function has been studied extensively. However, there is limited research on whether age interacts with the association between genetic polymorphisms and motor learning. We examined a group of young and older adults' performance in three motor tasks: explicit sequence learning, visuomotor adaptation, and grooved pegboard. We assessed whether individuals' motor learning and performance were associated with their age and genotypes. We selected three genetic polymorphisms: Catechol-O-Methyl Transferase (COMT val158met) and Dopamine D2 Receptor (DRD2 G>T), which are involved with dopaminergic regulation, and Brain Derived Neurotrophic Factor (BDNF val66met) that modulates neuroplasticity and has been shown to interact with dopaminergic genes. Although the underlying mechanisms of the function of these three genotypes are different, the high performance alleles of each have been linked to better learning and performance. We created a composite polygene score based on the Number of High Performance Alleles (NHPA) that each individual carried. We found several associations between genetic profile, motor performance, and sensorimotor adaptation. More importantly, we found that this association varies with age, task type, and engagement of implicit versus explicit learning processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.