Evidence map›Paper›PMID 26926495›Full record

ArticleFEMS yeast research2016

Get1p and Get2p are required for maintenance of mitochondrial morphology and normal cardiolipin levels.

Amit S Joshi, Naomi Fei, Miriam L Greenberg

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEMS yeast research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Amit S JoshiDepartment of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
Naomi FeiDepartment of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
Miriam L GreenbergDepartment of Biological Sciences, Wayne State University, Detroit, MI 48202, USA mgreenberg@wayne.edu.
Wayne State University · US

Funding

THE ROLE OF CARDIOLIPIN IN THE TCA CYCLE: IMPLICATIONS FOR BARTH SYNDROMER01HL117880 · NHLBI · WAYNE STATE UNIVERSITY · PI GREENBERG, MIRIAM L · 2014 to 2023
$3.0M
CARDIOLIPIN BIOSYNTHESIS AND FUNCTIONR01HL062263 · NHLBI · WAYNE STATE UNIVERSITY · PI GREENBERG, MIRIAM L · 2000 to 2004
$1.8M
NHLBI NIH HHS R01 HL062263NHLBI NIH HHS R01 HL 117880
6 · The paper itself

Abstract

Cardiolipin (CL) is the signature phospholipid of mitochondrial membranes. CL deficiency leads to defects in mitochondrial function. Using a targeted synthetic lethality screen to identify defects that exacerbate CL deficiency, we determined that deletion of mitochondrial morphology genes in cells lacking CL leads to severe growth defects. We show that ER membrane proteins Get1p and Get2p are required for maintaining normal levels of CL. We propose that these proteins regulate the level of CL by maintaining wild type-like tubular mitochondrial morphology. The genetic interactions observed in this study identify novel physiological modifiers that are required for maintenance of CL levels and mitochondrial morphology.

Indexed as

Adaptor Proteins, Vesicular TransportCardiolipinsGene DeletionGenetic TestingMembrane ProteinsMicrobial ViabilityMitochondriaSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAdaptor Proteins, Vesicular TransportCardiolipinsGET1 protein, S cerevisiaeGet2 protein, S cerevisiaeMembrane ProteinsSaccharomyces cerevisiae ProteinsBarth syndromecardiolipinmitochondria morphology

Identifiers

PMID26926495
PMCPMC5731434
OpenAlexW2291104258

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.