ArticleScientific reports2016
ES1 is a mitochondrial enlarging factor contributing to form mega-mitochondria in zebrafish cones.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
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- Climate Adaptation and Drift Shape the Genomes of Two Eel-Goby Sister Species Endemic to Contrasting Latitude.Animals : an open access journal from MDPI · 2023Article
- Etiology of Idiopathic Macular Holes in the Light of Estrogen Hormone.Current issues in molecular biology · 2023Review
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- Novel dicarbonyl metabolic pathway via mitochondrial ES1 possessing glyoxalase III activity.BBA advances · 2023Article
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- Estrogen-related receptor alpha in select host functions and cancer: new frontiers.Molecular and cellular biochemistry · 2022Review
- GATD3A, a mitochondrial deglycase with evolutionary origins from gammaproteobacteria, restricts the formation of advanced glycation end products.BMC biology · 2022Article
- Metabolism in the Zebrafish Retina.Journal of developmental biology · 2021Review
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- Daily mitochondrial dynamics in cone photoreceptors.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Data on mitochondrial ultrastructure of photoreceptors in pig, rabbit, and mouse retinas.Data in brief · 2020Article
- Copper induce zebrafish retinal developmental defects via triggering stresses and apoptosis.Cell communication and signaling : CCS · 2020Article
- Molecular analysis of population andHeliyon · 2020Article
- A novel cellular structure in the retina of insectivorous birds.Scientific reports · 2019Article
- Fishing in the Cell Powerhouse: Zebrafish as A Tool for Exploration of Mitochondrial Defects Affecting the Nervous System.International journal of molecular sciences · 2019Review
- Phagosomal and mitochondrial alterations in RPE may contribute to KCNJ13 retinopathy.Scientific reports · 2019Article
- SS-31 Peptide Reverses the Mitochondrial Fragmentation Present in Fibroblasts From Patients With DCMA, a Mitochondrial Cardiomyopathy.Frontiers in cardiovascular medicine · 2019Article
- Multimodal LA-ICP-MS and nanoSIMS imaging enables copper mapping within photoreceptor megamitochondria in a zebrafish model of Menkes disease.Metallomics : integrated biometal science · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Total mass of mitochondria increases during cell proliferation and differentiation through mitochondrial biogenesis, which includes mitochondrial proliferation and growth. During the mitochondrial growth, individual mitochondria have been considered to be enlarged independently of mitochondrial fusion. However, molecular basis for this enlarging process has been poorly understood. Cone photoreceptor cells in the retina possess large mitochondria, so-called mega-mitochondria that have been considered to arise via the enlarging process. Here we show that ES1 is a novel mitochondria-enlarging factor contributing to form mega-mitochondria in cones. ES1 is specifically expressed in cones and localized to mitochondria including mega-mitochondria. Knockdown of ES1 markedly reduced the mitochondrial size in cones. In contrast, ectopic expression of ES1 in rods significantly increased both the size of individual mitochondria and the total mass of the mitochondrial cluster without changing the number of them. RNA-seq analysis showed that ERRα and its downstream mitochondrial genes were significantly up-regulated in the ES1-expressing rods, suggesting facilitation of mitochondrial enlargement via ERRα-dependent processes. Furthermore, higher energy state was detected in the ES1-expressing rods, indicating that the enlarged mitochondria by ES1 are capable of producing high energy. ES1 is the mitochondrial protein that is first found to promote enlargement of individual mitochondria.
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