Evidence map›Paper›PMID 26926391›Full record

ArticleCell research2016

Duchenne muscular dystrophy: CRISPR/Cas9 treatment.

Jerry R Mendell, Louise R Rodino-Klapac

Abstract readComment
In one paragraph

Article in Cell research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Review
  2. Article
  3. Mitochondria: emerging therapeutic strategies for oocyte rescue.Reproductive sciences (Thousand Oaks, Calif.) · 2022
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Neuromuscular diseases rehabilitation in the era of gene therapy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Article
  12. Review
  13. CRISPR/Cas9-Mediated miR-29b Editing as a Treatment of Different Types of Muscle Atrophy in Mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2020
    Article
  14. Article
  15. Stem Cell Aging in Skeletal Muscle Regeneration and Disease.International journal of molecular sciences · 2020
    Review
  16. Review
  17. [A review of gene therapy for Duchenne muscular dystrophy].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2018
    Review
  18. Current and Emerging Therapies for Duchenne Muscular Dystrophy.Current treatment options in neurology · 2018
    Review
  19. Molecular Therapies for Muscular Dystrophies.Current treatment options in neurology · 2018
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Jerry R MendellDepartment of Pediatrics, Columbus, OH 43205, USA.
Louise R Rodino-KlapacDepartment of Pediatrics, Columbus, OH 43205, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel approach to gene correction by genome editing shows great promise as a treatment for Duchenne muscular dystrophy (DMD). CRISPR/Cas9 delivered by adeno-associated virus to a mouse model for DMD demonstrated improvement in function and histology.

Indexed as

AnimalsCRISPR-Cas SystemsDystrophinGenetic TherapyHumansInfant, NewbornMiceMuscular Dystrophy, DuchenneNeonatal ScreeningDystrophin

Identifiers

PMID26926391
PMCPMC4856761

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.