ArticleCirculation. Cardiovascular imaging2016
Quantifying the Area at Risk in Reperfused ST-Segment-Elevation Myocardial Infarction Patients Using Hybrid Cardiac Positron Emission Tomography-Magnetic Resonance Imaging.
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Article in Circulation. Cardiovascular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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30citing papers in PubMed, 2 pooled it
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30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Comparison of cardiac magnetic resonance imaging and fluorodeoxyglucose positron emission tomography in the assessment of myocardial viability: meta-analysis and systematic review.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Pooled it
- Cardiovascular magnetic resonance native TJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020Pooled it
- Effects of different strategies on high thrombus burden in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary catheterization.Coronary artery disease · 2019Trial
- Comparison of the distribution and functional significance of myocardial fibroblast activation and inflammation in reperfused ST-elevation myocardial infarction.Quantitative imaging in medicine and surgery · 2026Article
- Spatial FAP Expression as Detected byMolecular imaging and biology · 2025Article
- A non-invasive osteopontin-targeted phase changeable fluorescent nanoprobe for molecular imaging of myocardial fibrosis.Nanoscale advances · 2024Article
- Emerging molecular imaging targets and tools for myocardial fibrosis detection.European heart journal. Cardiovascular Imaging · 2023Article
- The PARADISE-MI trial: a new opportunity to improve the left ventricular remodelling in reperfused STEMI.ESC heart failure · 2022Article
- The Bright Side of Myocardial Edema.Journal of the American Heart Association · 2021Article
- Imaging tools for assessment of myocardial fibrosis in humans: the need for greater detail.Biophysical reviews · 2020Review
- Motion-corrected whole-heart PET-MR for the simultaneous visualisation of coronary artery integrity and myocardial viability: an initial clinical validation.European journal of nuclear medicine and molecular imaging · 2018Article
- CouldJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Cardiovascular Magnetic Resonance in Acute ST-Segment-Elevation Myocardial Infarction: Recent Advances, Controversies, and Future Directions.Circulation · 2018Review
- Fusion of CT coronary angiography and whole-heart dynamic 3D cardiac MR perfusion: building a framework for comprehensive cardiac imaging.The international journal of cardiovascular imaging · 2018Article
- Multi-modality imaging evaluation of recurrent Tako-tsubo syndrome in a patient with coronary artery fibromuscular dysplasia.Cardiovascular ultrasound · 2017Article
- Redefining viability by cardiovascular magnetic resonance in acute ST-segment elevation myocardial infarction.Scientific reports · 2017Article
- MR/PET Imaging of the Cardiovascular System.JACC. Cardiovascular imaging · 2017Review
- Quantification of both the area-at-risk and acute myocardial infarct size in ST-segment elevation myocardial infarction using T1-mapping.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2017Article
- PET-CMR in heart failure - synergistic or redundant imaging?Heart failure reviews · 2017Review
- The role of myocardial viability in contemporary cardiac practice.Heart failure reviews · 2017Review
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Authors and funding
15 authors at 6 institutions in 2 countries.
Heerajnarain BulluckFrom the The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK (H.B., S.K.W., G.M.F., A.N., D.M.Y., D.J.H.); The National Institute of Health Research, University College London Hospitals Biomedical Research Centre, UK (H.B., S.K.W., A.S., J.C.M., D.M.Y., D.J.H.); Independent Researcher (S.G.C.); UCL Institute of Nuclear Medicine, University College London Hospital, UK (C.O., S.M.Y.W., A.G., L.M.); London School Hygiene and Tropical Medicine, London, UK (J.N.); Siemens Healthcare, Frimley, UK (P.W.); Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore (D.J.H.); and National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore (D.J.H.).
Steven K WhiteFrom the The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK (H.B., S.K.W., G.M.F., A.N., D.M.Y., D.J.H.); The National Institute of Health Research, University College London Hospitals Biomedical Research Centre, UK (H.B., S.K.W., A.S., J.C.M., D.M.Y., D.J.H.); Independent Researcher (S.G.C.); UCL Institute of Nuclear Medicine, University College London Hospital, UK (C.O., S.M.Y.W., A.G., L.M.); London School Hygiene and Tropical Medicine, London, UK (J.N.); Siemens Healthcare, Frimley, UK (P.W.); Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore (D.J.H.); and National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore (D.J.H.). stevenkwhite@gmail.com.
Georg M FröhlichFrom the The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK (H.B., S.K.W., G.M.F., A.N., D.M.Y., D.J.H.); The National Institute of Health Research, University College London Hospitals Biomedical Research Centre, UK (H.B., S.K.W., A.S., J.C.M., D.M.Y., D.J.H.); Independent Researcher (S.G.C.); UCL Institute of Nuclear Medicine, University College London Hospital, UK (C.O., S.M.Y.W., A.G., L.M.); London School Hygiene and Tropical Medicine, London, UK (J.N.); Siemens Healthcare, Frimley, UK (P.W.); Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore (D.J.H.); and National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore (D.J.H.).
Steven G CassonFrom the The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK (H.B., S.K.W., G.M.F., A.N., D.M.Y., D.J.H.); The National Institute of Health Research, University College London Hospitals Biomedical Research Centre, UK (H.B., S.K.W., A.S., J.C.M., D.M.Y., D.J.H.); Independent Researcher (S.G.C.); UCL Institute of Nuclear Medicine, University College London Hospital, UK (C.O., S.M.Y.W., A.G., L.M.); London School Hygiene and Tropical Medicine, London, UK (J.N.); Siemens Healthcare, Frimley, UK (P.W.); Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore (D.J.H.); and National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore (D.J.H.).
Celia O'MearaFrom the The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK (H.B., S.K.W., G.M.F., A.N., D.M.Y., D.J.H.); The National Institute of Health Research, University College London Hospitals Biomedical Research Centre, UK (H.B., S.K.W., A.S., J.C.M., D.M.Y., D.J.H.); Independent Researcher (S.G.C.); UCL Institute of Nuclear Medicine, University College London Hospital, UK (C.O., S.M.Y.W., A.G., L.M.); London School Hygiene and Tropical Medicine, London, UK (J.N.); Siemens Healthcare, Frimley, UK (P.W.); Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore (D.J.H.); and National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore (D.J.H.).
Ayla NewtonFrom the The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK (H.B., S.K.W., G.M.F., A.N., D.M.Y., D.J.H.); The National Institute of Health Research, University College London Hospitals Biomedical Research Centre, UK (H.B., S.K.W., A.S., J.C.M., D.M.Y., D.J.H.); Independent Researcher (S.G.C.); UCL Institute of Nuclear Medicine, University College London Hospital, UK (C.O., S.M.Y.W., A.G., L.M.); London School Hygiene and Tropical Medicine, London, UK (J.N.); Siemens Healthcare, Frimley, UK (P.W.); Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore (D.J.H.); and National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore (D.J.H.).
Jennifer NicholasFrom the The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK (H.B., S.K.W., G.M.F., A.N., D.M.Y., D.J.H.); The National Institute of Health Research, University College London Hospitals Biomedical Research Centre, UK (H.B., S.K.W., A.S., J.C.M., D.M.Y., D.J.H.); Independent Researcher (S.G.C.); UCL Institute of Nuclear Medicine, University College London Hospital, UK (C.O., S.M.Y.W., A.G., L.M.); London School Hygiene and Tropical Medicine, London, UK (J.N.); Siemens Healthcare, Frimley, UK (P.W.); Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore (D.J.H.); and National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore (D.J.H.).
Peter WealeFrom the The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK (H.B., S.K.W., G.M.F., A.N., D.M.Y., D.J.H.); The National Institute of Health Research, University College London Hospitals Biomedical Research Centre, UK (H.B., S.K.W., A.S., J.C.M., D.M.Y., D.J.H.); Independent Researcher (S.G.C.); UCL Institute of Nuclear Medicine, University College London Hospital, UK (C.O., S.M.Y.W., A.G., L.M.); London School Hygiene and Tropical Medicine, London, UK (J.N.); Siemens Healthcare, Frimley, UK (P.W.); Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore (D.J.H.); and National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore (D.J.H.).
Simon M Y WanFrom the The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK (H.B., S.K.W., G.M.F., A.N., D.M.Y., D.J.H.); The National Institute of Health Research, University College London Hospitals Biomedical Research Centre, UK (H.B., S.K.W., A.S., J.C.M., D.M.Y., D.J.H.); Independent Researcher (S.G.C.); UCL Institute of Nuclear Medicine, University College London Hospital, UK (C.O., S.M.Y.W., A.G., L.M.); London School Hygiene and Tropical Medicine, London, UK (J.N.); Siemens Healthcare, Frimley, UK (P.W.); Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore (D.J.H.); and National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore (D.J.H.).
Alex SirkerFrom the The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK (H.B., S.K.W., G.M.F., A.N., D.M.Y., D.J.H.); The National Institute of Health Research, University College London Hospitals Biomedical Research Centre, UK (H.B., S.K.W., A.S., J.C.M., D.M.Y., D.J.H.); Independent Researcher (S.G.C.); UCL Institute of Nuclear Medicine, University College London Hospital, UK (C.O., S.M.Y.W., A.G., L.M.); London School Hygiene and Tropical Medicine, London, UK (J.N.); Siemens Healthcare, Frimley, UK (P.W.); Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore (D.J.H.); and National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore (D.J.H.).
James C MoonFrom the The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK (H.B., S.K.W., G.M.F., A.N., D.M.Y., D.J.H.); The National Institute of Health Research, University College London Hospitals Biomedical Research Centre, UK (H.B., S.K.W., A.S., J.C.M., D.M.Y., D.J.H.); Independent Researcher (S.G.C.); UCL Institute of Nuclear Medicine, University College London Hospital, UK (C.O., S.M.Y.W., A.G., L.M.); London School Hygiene and Tropical Medicine, London, UK (J.N.); Siemens Healthcare, Frimley, UK (P.W.); Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore (D.J.H.); and National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore (D.J.H.).
Derek M YellonFrom the The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK (H.B., S.K.W., G.M.F., A.N., D.M.Y., D.J.H.); The National Institute of Health Research, University College London Hospitals Biomedical Research Centre, UK (H.B., S.K.W., A.S., J.C.M., D.M.Y., D.J.H.); Independent Researcher (S.G.C.); UCL Institute of Nuclear Medicine, University College London Hospital, UK (C.O., S.M.Y.W., A.G., L.M.); London School Hygiene and Tropical Medicine, London, UK (J.N.); Siemens Healthcare, Frimley, UK (P.W.); Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore (D.J.H.); and National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore (D.J.H.).
Ashley GrovesFrom the The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK (H.B., S.K.W., G.M.F., A.N., D.M.Y., D.J.H.); The National Institute of Health Research, University College London Hospitals Biomedical Research Centre, UK (H.B., S.K.W., A.S., J.C.M., D.M.Y., D.J.H.); Independent Researcher (S.G.C.); UCL Institute of Nuclear Medicine, University College London Hospital, UK (C.O., S.M.Y.W., A.G., L.M.); London School Hygiene and Tropical Medicine, London, UK (J.N.); Siemens Healthcare, Frimley, UK (P.W.); Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore (D.J.H.); and National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore (D.J.H.).
Leon MenezesFrom the The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK (H.B., S.K.W., G.M.F., A.N., D.M.Y., D.J.H.); The National Institute of Health Research, University College London Hospitals Biomedical Research Centre, UK (H.B., S.K.W., A.S., J.C.M., D.M.Y., D.J.H.); Independent Researcher (S.G.C.); UCL Institute of Nuclear Medicine, University College London Hospital, UK (C.O., S.M.Y.W., A.G., L.M.); London School Hygiene and Tropical Medicine, London, UK (J.N.); Siemens Healthcare, Frimley, UK (P.W.); Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore (D.J.H.); and National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore (D.J.H.).
Derek J HausenloyFrom the The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK (H.B., S.K.W., G.M.F., A.N., D.M.Y., D.J.H.); The National Institute of Health Research, University College London Hospitals Biomedical Research Centre, UK (H.B., S.K.W., A.S., J.C.M., D.M.Y., D.J.H.); Independent Researcher (S.G.C.); UCL Institute of Nuclear Medicine, University College London Hospital, UK (C.O., S.M.Y.W., A.G., L.M.); London School Hygiene and Tropical Medicine, London, UK (J.N.); Siemens Healthcare, Frimley, UK (P.W.); Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore (D.J.H.); and National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore (D.J.H.).
Siemens (United Kingdom) · GBOldham Council · GBLondon School of Hygiene & Tropical Medicine · GBUniversity College London · GBNational University of Singapore · SGUniversity College Hospital · GB
Funding
British Heart Foundation FS/10/039/28270British Heart Foundation FS/10/40/28260British Heart Foundation FS/10/72/28568British Heart Foundation FS/12/56/29723
Abstract
backgroundHybrid positron emission tomography and magnetic resonance allows the advantages of magnetic resonance in tissue characterizing the myocardium to be combined with the unique metabolic insights of positron emission tomography. We hypothesized that the area of reduced myocardial glucose uptake would closely match the area at risk delineated by T2 mapping in ST-segment-elevation myocardial infarction patients. METHODS AND
resultsHybrid positron emission tomography and magnetic resonance using (18)F-fluorodeoxyglucose (FDG) for glucose uptake was performed in 21 ST-segment-elevation myocardial infarction patients at a median of 5 days. Follow-up scans were performed in a subset of patients 12 months later. The area of reduced FDG uptake was significantly larger than the infarct size quantified by late gadolinium enhancement (37.2±11.6% versus 22.3±11.7%; P<0.001) and closely matched the area at risk by T2 mapping (37.2±11.6% versus 36.3±12.2%; P=0.10, R=0.98, bias 0.9±4.4%). On the follow-up scans, the area of reduced FDG uptake was significantly smaller in size when compared with the acute scans (19.5 [6.3%-31.8%] versus 44.0 [21.3%-55.3%]; P=0.002) and closely correlated with the areas of late gadolinium enhancement (R 0.98) with a small bias of 2.0±5.6%. An FDG uptake of ≥45% on the acute scans could predict viable myocardium on the follow-up scan. Both transmural extent of late gadolinium enhancement and FDG uptake on the acute scan performed equally well to predict segmental wall motion recovery.
conclusionsHybrid positron emission tomography and magnetic resonance in the reperfused ST-segment-elevation myocardial infarction patients showed reduced myocardial glucose uptake within the area at risk and closely matched the area at risk delineated by T2 mapping. FDG uptake, as well as transmural extent of late gadolinium enhancement, acutely can identify viable myocardial segments.
Indexed as
Coronary CirculationMagnetic Resonance Imaging, CinePercutaneous Coronary InterventionPositron-Emission TomographyAgedContrast MediaFemaleFluorodeoxyglucose F18Heterocyclic CompoundsHumansImage Interpretation, Computer-AssistedMaleMiddle AgedMultimodal ImagingMyocardial InfarctionMyocardial Perfusion ImagingContrast MediaFluorodeoxyglucose F18gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetateHeterocyclic CompoundsOrganometallic CompoundsRadiopharmaceuticalsarea at riskcardiovascular magnetic resonance imagingF-flurodeoxyglucosehybrid PET-MR imaginginfarct sizepositron emission tomographyST-segment–elevation myocardial infarctionT2 mappingviability
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