Evidence map›Paper›PMID 26926152›Full record

ArticleJournal of the Association for Research in Otolaryngology : JARO2016

Assessing the Electrode-Neuron Interface with the Electrically Evoked Compound Action Potential, Electrode Position, and Behavioral Thresholds.

Lindsay DeVries, Rachel Scheperle, Julie Arenberg Bierer

Abstract read
In one paragraph

Article in Journal of the Association for Research in Otolaryngology : JARO, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. A systematic review of electrode array scalar dislocation after cochlear implant surgery.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Pooled it
  2. Angular Electrode Insertion Depth and Speech Perception in Adults With a Cochlear Implant: A Systematic Review.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2019
    Pooled it
  3. Trial
  4. Imaging evaluation of electrode placement and effect on electrode discrimination on different cochlear implant electrode arrays.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018
    Trial
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. An Electrically Evoked Compound Action Potential Marker for Local Spiral Ganglion Neuron Degeneration: The Failure Index.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  13. Article
  14. Article
  15. Review
  16. ART and AutoART ECAP measurements and cochlear nerve anatomy as predictors in adult cochlear implant recipients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  17. How to vocode: Using channel vocoders for cochlear-implant research.The Journal of the Acoustical Society of America · 2024
    Article
  18. Peripheral neural synchrony in post-lingually deafened adult cochlear implant users.medRxiv : the preprint server for health sciences · 2024
    Article
  19. Article
  20. Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lindsay DeVriesDepartment of Speech and Hearing Sciences, University of Washington, 4131 15th Ave NE, Seattle, WA, 98105, USA. lindsdev@uw.edu.
Rachel ScheperleDepartment of Communication Sciences and Disorders, Wendell Johnson Speech and Hearing Center, University of Iowa, Iowa City, Iowa, 52242, USA.
Julie Arenberg BiererDepartment of Speech and Hearing Sciences, University of Washington, 4131 15th Ave NE, Seattle, WA, 98105, USA.

Funding

UNIVERSITY OF WASHINGTON RESEARCH CORE CENTERP30DC004661 · NIDCD · UNIVERSITY OF WASHINGTON · PI PHILLIPS, JAMES O, TEMPEL, BRUCE L · 2000 to 2014
$11.1M
Perceptual implications of cochlear implant electrode-neuron interfacesR01DC012142 · NIDCD · UNIVERSITY OF WASHINGTON · PI JULIE G Arenberg · 2012 to 2026
$6.5M
Training Program in Hearing and BalanceT32DC000033 · NIDCD · UNIVERSITY OF WASHINGTON · PI WERNER, LYNNE A. · 1991 to 2015
$3.9M
NIDCD NIH HHS P30 DC004661NIDCD NIH HHS R01 DC012142NIDCD NIH HHS T32 DC000033
6 · The paper itself

Abstract

Variability in speech perception scores among cochlear implant listeners may largely reflect the variable efficacy of implant electrodes to convey stimulus information to the auditory nerve. In the present study, three metrics were applied to assess the quality of the electrode-neuron interface of individual cochlear implant channels: the electrically evoked compound action potential (ECAP), the estimation of electrode position using computerized tomography (CT), and behavioral thresholds using focused stimulation. The primary motivation of this approach is to evaluate the ECAP as a site-specific measure of the electrode-neuron interface in the context of two peripheral factors that likely contribute to degraded perception: large electrode-to-modiolus distance and reduced neural density. Ten unilaterally implanted adults with Advanced Bionics HiRes90k devices participated. ECAPs were elicited with monopolar stimulation within a forward-masking paradigm to construct channel interaction functions (CIF), behavioral thresholds were obtained with quadrupolar (sQP) stimulation, and data from imaging provided estimates of electrode-to-modiolus distance and scalar location (scala tympani (ST), intermediate, or scala vestibuli (SV)) for each electrode. The width of the ECAP CIF was positively correlated with electrode-to-modiolus distance; both of these measures were also influenced by scalar position. The ECAP peak amplitude was negatively correlated with behavioral thresholds. Moreover, subjects with low behavioral thresholds and large ECAP amplitudes, averaged across electrodes, tended to have higher speech perception scores. These results suggest a potential clinical role for the ECAP in the objective assessment of individual cochlear implant channels, with the potential to improve speech perception outcomes.

Indexed as

Cochlear ImplantsSpeech PerceptionAction PotentialsAdultAgedAged, 80 and overAuditory ThresholdElectrodes, ImplantedHumansMiddle AgedNeuronsTomography, X-Ray Computedcochlear implantselectrically evoked compound action potentialelectrode configurationimagingpsychophysics

Identifiers

PMID26926152
PMCPMC4854826

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.