ArticleEye & contact lens2017
Characteristics of Ocular Pain Complaints in Patients With Idiopathic Dry Eye Symptoms.
Article in Eye & contact lens, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04648085 (Effect of Trigeminal Nerve Stimulation on Subbasal Corneal Nerve Plexus Density and Chronic Ocular Pain in Patients With Dry Eye), which is not on this map. Cited by 66 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Trigeminal Nerve Stimulation on Subbasal Corneal Nerve Plexus Density and Chronic Ocular Pain in Patients With Dry Eye
Who cites it
66 citing papers in PubMed, 100 citations in OpenAlex.
- Electroacupuncture promotes the repair of lacrimal glands damage in dry-eye animal models by modulating the BDNF/CREB signaling pathway.Journal of traditional and complementary medicine · 2026Article
- Chronic ocular pain is associated with smaller selective hippocampal subfield in highly symptomatic patients.The journal of pain · 2026Article
- Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry.Arthritis care & research · 2026Article
- Mechanism of periocular acupuncture in alleviating dry eye neuropathic pain via regulation of the "periocular acupoint-trigeminal ganglion-ventral posteromedial thalamic nucleus" pathway.Frontiers in medicine · 2026Article
- Prolonged aftersensations to thermal noxious stimulation as a screening tool for central contributions to chronic ocular pain.The journal of pain · 2026Article
- Heightened visual light sensitivity discomfort measured by the ocular photosensitivity analyzer is associated with chronic ocular pain.The ocular surface · 2025Article
- The eye as a window to oral and pain symptoms in Sjögren's disease.The British journal of ophthalmology · 2025Article
- Impact of botulinum toxin type A on ocular pain with neuropathic features.The ocular surface · 2025Article
- Long-Term Evolution of Chronic Neuropathic Ocular Pain and Dry Eye Following Corneal Refractive Surgery.Journal of clinical medicine · 2025Article
- CORONIS symposium 2023: Scientific and clinical frontiers in ocular surface innervation.Acta ophthalmologica · 2025Article
- Dry eye disease and psychosomatics-benefits of mind-body therapy for dry eye disease.Frontiers in medicine · 2025Review
- Abnormal visual cortex activity using functional magnetic resonance imaging in treatment resistant photophobia in Friedreich Ataxia.American journal of ophthalmology case reports · 2024Article
- Observational Clinical Investigation Evaluating an Ophthalmic Solution Containing Xanthan Gum and Low Concentration Desonide Phosphate in Dry Eye Disease Treatment.Ophthalmology and therapy · 2024Article
- The relationship between dry eye disease and human microbiota: A review of the science.Experimental eye research · 2024Review
- Review
- Role of Polyunsaturated Fatty Acids (PUFAs) and Eicosanoids on Dry Eye Symptoms and Signs.Biomolecules · 2024Article
- FL-41 Tint Reduces Activation of Neural Pathways of Photophobia in Patients with Chronic Ocular Pain.American journal of ophthalmology · 2024Article
- Utilizing visual symptoms to distinguish dry eye from glaucoma, cataract, and suspect glaucoma patients: a cross-sectional study.BMC ophthalmology · 2024Article
- Influencing factors of ocular pain in dry eye disease patients at high altitude.International journal of ophthalmology · 2024Article
- Ocular Pain after Refractive Surgery: Interim Analysis of Frequency and Risk Factors.Ophthalmology · 2023Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThe purpose of this study was to examine the severity and quality of ocular pain complaints in patients with dry eye symptoms.
methodsSubjects with clinically relevant dry eye symptoms (dryness, discomfort, tearing) of unknown origin seen in the Miami Veterans Affairs eye clinic were administered questionnaires for dry eye symptoms and ocular pain and underwent a standardized ocular examination. Qualities and severity ratings of ocular pain in subjects with idiopathic dry eye were compared with similar measures from published data in other chronic pain populations.
resultsThe study sample consisted of 154 subjects, of which 91% were men and ranged in age from 27 to 89 (mean age=61). Fifty-three percent of participants reported an average ocular pain of at least moderate intensity (numerical rating scale≥4), with specific characteristics (i.e., "burning" spontaneous pain) reported at frequencies comparable to prevalent chronic neuropathic pain syndromes as reported in the literature. Significant correlations were found between ocular pain metrics and dry eye symptom severity scores (r=0.57-0.66). Dry eye signs, however, did not generally correlate with ocular pain severity.
conclusionsA significant proportion of subjects with idiopathic dry eye symptoms reported moderate or greater ocular pain intensity, with most endorsing descriptors commonly used by patients with nonocular neuropathic pain conditions. Identifying subgroups of dry eye patients based on the presence and characteristics of ocular pain complaints may improve dry eye subclassification and better individualize treatment strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.