ArticleRegenerative medicine2016
Rational design of an improved tissue-engineered vascular graft: determining the optimal cell dose and incubation time.
Article in Regenerative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04467671 (Prospective, Open-labeled, Single-arm Clinical Trial to Evaluate the Safety and Efficacy of the Second-generation Tissue Engineered Vascular Graft as Vascular Conduits for Extracardiac Total Cavopulmonary Connection.), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective, Open-labeled, Single-arm Clinical Trial to Evaluate the Safety and Efficacy of the Second-generation Tissue Engineered Vascular Graft as Vascular Conduits for Extracardiac Total Cavopulmonary Connection.
Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Tissue-engineered Vascular Grafts in Children With Congenital Heart Disease: Intermediate Term Follow-up.Seminars in thoracic and cardiovascular surgery · 2018Trial
- Tissue Engineering of Vascular Grafts: A Case Report From Bench to Bedside and Back.Arteriosclerosis, thrombosis, and vascular biology · 2023Review
- Review
- Tissue engineered vascular grafts transform into autologous neovessels capable of native function and growth.Communications medicine · 2022Article
- CCL2 loaded microparticles promote acute patency in silk-based vascular grafts implanted in rat aortae.Acta biomaterialia · 2021Article
- In vivo implantation of 3-dimensional printed customized branched tissue engineered vascular graft in a porcine model.The Journal of thoracic and cardiovascular surgery · 2020Article
- Spontaneous reversal of stenosis in tissue-engineered vascular grafts.Science translational medicine · 2020Article
- Review on Mechanical Support and Cell-Based Therapies for the Prevention and Recovery of the Failed Fontan-Kreutzer Circulation.Frontiers in pediatrics · 2020Review
- Development of a Semi-Automated, Bulk Seeding Device for Large Animal Model Implantation of Tissue Engineered Vascular Grafts.Frontiers in bioengineering and biotechnology · 2020Article
- Progressive Reinvention or Destination Lost? Half a Century of Cardiovascular Tissue Engineering.Frontiers in cardiovascular medicine · 2020Review
- Early natural history of neotissue formation in tissue-engineered vascular grafts in a murine model.Regenerative medicine · 2019Article
- Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair.Cell reports · 2019Article
- Magnetic Resonance Imaging of Shear Stress and Wall Thickness in Tissue-Engineered Vascular Grafts.Tissue engineering. Part C, Methods · 2018Article
- Role of Bone Marrow Mononuclear Cell Seeding for Nanofiber Vascular Grafts.Tissue engineering. Part A · 2018Article
- Future Perspectives on the Role of Stem Cells and Extracellular Vesicles in Vascular Tissue Regeneration.Frontiers in cardiovascular medicine · 2018Review
- Tissue-engineered vascular grafts for congenital cardiac disease: Clinical experience and current status.Trends in cardiovascular medicine · 2017Review
- Improving in vivo outcomes of decellularized vascular grafts via incorporation of a novel extracellular matrix.Biomaterials · 2017Article
- The role of myeloid cell-derived PDGF-B in neotissue formation in a tissue-engineered vascular graft.Regenerative medicine · 2017Article
- Deconstructing the Tissue Engineered Vascular Graft: Evaluating Scaffold Pre-Wetting, Conditioned Media Incubation, and Determining the Optimal Mononuclear Cell Source.ACS biomaterials science & engineering · 2017Article
- Toward a patient-specific tissue engineered vascular graft.Journal of tissue engineeringArticle
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
aimWe investigated the effect of cell seeding dose and incubation time on tissue-engineered vascular graft (TEVG) patency. MATERIALS &
methodsVarious doses of bone marrow-derived mononuclear cells (BM-MNCs) were seeded onto TEVGs, incubated for 0 or 12 h, and implanted in C57BL/6 mice. Different doses of human BM-MNCs were seeded onto TEVGs and measured for cell attachment.
resultsThe incubation time showed no significant effect on TEVG patency. However, TEVG patency was significantly increased in a dose-dependent manner. In the human graft, more bone marrow used for seeding resulted in increased cell attachment in a dose-dependent manner.
conclusionIncreasing the BM-MNC dose and reducing incubation time is a viable strategy for improving the performance and utility of the graft.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.