Evidence map›Paper›PMID 26925500›Full record

ReviewAnnual review of pathology2016

Mechanisms of Disease of Eosinophilic Esophagitis.

Benjamin P Davis, Marc E Rothenberg

Open access · greenAbstract readReview
In one paragraph

Review in Annual review of pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 4 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 4 syntheses or guidelines pooled it, 89 citations in OpenAlex.

  1. Pooled it
  2. AGA Clinical Practice Update on Esophageal Dysfunction Due to Disordered Immunity and Infection: Expert Review.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024
    Guideline
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Article
  8. Sexual Dimorphism in Allergic and Mast Cell-Associated Diseases.Clinical reviews in allergy & immunology · 2026
    Review
  9. Review
  10. Article
  11. Immune functions of the esophagus.The Journal of allergy and clinical immunology · 2026
    Review
  12. Review
  13. Review
  14. Cow milk protein allergy mimics in infancy.World journal of clinical pediatrics · 2025
    Review
  15. Mouse models of eosinophilic esophagitis: molecular and translational insights.American journal of physiology. Gastrointestinal and liver physiology · 2025
    Review
  16. Review
  17. Exploring the Impact of Gender on the Characteristics and Complications of Eosinophilic Esophagitis.JGH open : an open access journal of gastroenterology and hepatology · 2024
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Benjamin P DavisDivision of Immunology, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242; email: ben-davis@uiowa.edu.
Marc E RothenbergDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229; email: rothenberg@cchmc.org.
Cincinnati Children's Hospital Medical Center · USUniversity of Iowa Hospitals and Clinics · US

Funding

Mechanistic CoreU19AI066738 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SAMPSON, HUGH A · 2005 to 2016
$43.6M
TSLP, IL-9-producing mucosal mast cells, and allergic inflammationU19AI070235 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI Marc E. Rothenberg · 2006 to 2026
$31.3M
Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4M
TRAINING (CAREER DEVELOPMENT) COMPONENTU54AI117804 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI GLENN T FURUTA, Marc E. Rothenberg · 2014 to 2026
$18.5M
Pulmonary Development and Disease Pathogenesis Training ProgramT32HL007752 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Francis Xavier McCormack, Anne-Karina Theresia Perl · 1994 to 2026
$6.3M
Role of IL-15 in the Pathogensis of Eosinophilic EsophagitisR01AI080581 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI MISHRA, ANIL · 2009 to 2023
$4.9M
Regulation of Gastrointestinal EosinophilsR37AI045898 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI ROTHENBERG, MARC E. · 2010 to 2019
$3.6M
IL-13 and Eosinophilic EsophagitisR01DK076893 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI ROTHENBERG, MARC E. · 2007 to 2011
$3.1M
Immunology/Allergy Fellowship Training GrantT32AI060515 · NIAID · UNIVERSITY OF CINCINNATI · PI BERNSTEIN, DAVID I., ROTHENBERG, MARC E. · 2004 to 2018
$2.8M
Mechanistic Analysis of Eosinophilic Esophagitis.R01DK067255 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI MISHRA, ANIL · 2005 to 2014
$2.6M
Eosinophil, Chemokine and IL-13 Cooperativity in AsthmaR01AI057803 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI ROTHENBERG, MARC E. · 2004 to 2007
$731k
NHLBI NIH HHS T32 HL007752NIAID NIH HHS R01 AI057803NIAID NIH HHS R01 AI080581NIAID NIH HHS R37 AI045898NIAID NIH HHS T32 AI060515NIAID NIH HHS U19 AI066738NIAID NIH HHS U19 AI070235NIAID NIH HHS U54 AI117804NIDDK NIH HHS P30 DK078392NIDDK NIH HHS R01 DK067255NIDDK NIH HHS R01 DK076893
6 · The paper itself

Abstract

Eosinophilic esophagitis (EoE) is a recently recognized inflammatory disease of the esophagus with clinical symptoms derived from esophageal dysfunction. The etiology of EoE is now being elucidated, and food hypersensitivity is emerging as the central cornerstone of disease pathogenesis. Herein, we present a thorough picture of the current clinical, pathologic, and molecular understanding of the disease with a focus on disease mechanisms.

Indexed as

Eosinophilic EsophagitisFood HypersensitivityHumansatopybarrier dysfunctioneosinophilic esophagitisepithelial inflammationfibrosis

Identifiers

PMID26925500
PMCPMC4918086
OpenAlexW2096624324

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.