ArticlePeerJ2016
RNA-Seq of the Caribbean reef-building coral Orbicella faveolata (Scleractinia-Merulinidae) under bleaching and disease stress expands models of coral innate immunity.
Article in PeerJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 64 citations in OpenAlex.
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- Evolution and Function of the Notch Signaling Pathway: An Invertebrate Perspective.International journal of molecular sciences · 2024Review
- Transcriptomic signatures across a critical sedimentation threshold in a major reef-building coral.Frontiers in physiology · 2024Article
- The coral microbiome: towards an understanding of the molecular mechanisms of coral-microbiota interactions.FEMS microbiology reviews · 2023Article
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- Disease resistance in coral is mediated by distinct adaptive and plastic gene expression profiles.Science advances · 2022Article
- The Skeleton and Biomineralization Mechanism as Part of the Innate Immune System of Stony Corals.Frontiers in immunology · 2022Review
- Review
- Microbial community and transcriptional responses to increased temperatures in coral Pocillopora damicornis holobiont.Environmental microbiology · 2021Article
- Energy depletion and opportunistic microbial colonisation in white syndrome lesions from corals across the Indo-Pacific.Scientific reports · 2020Article
- First sequencing of ancient coral skeletal proteins.Scientific reports · 2020Article
- Looking Down on NF-κB.Molecular and cellular biology · 2020Review
- Ecological Factors Mediate Immunity and Parasitic Co-Infection in Sea Fan Octocorals.Frontiers in immunology · 2020Article
- Innate immune gene expression in Acropora palmata is consistent despite variance in yearly disease events.PloS one · 2020Article
- Differential gene expression analysis of symbiotic and aposymbioticEcology and evolution · 2019Article
- Article
- Comparative analysis of the Pocillopora damicornis genome highlights role of immune system in coral evolution.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Climate change-driven coral disease outbreaks have led to widespread declines in coral populations. Early work on coral genomics established that corals have a complex innate immune system, and whole-transcriptome gene expression studies have revealed mechanisms by which the coral immune system responds to stress and disease. The present investigation expands bioinformatic data available to study coral molecular physiology through the assembly and annotation of a reference transcriptome of the Caribbean reef-building coral, Orbicella faveolata. Samples were collected during a warm water thermal anomaly, coral bleaching event and Caribbean yellow band disease outbreak in 2010 in Puerto Rico. Multiplex sequencing of RNA on the Illumina GAIIx platform and de novo transcriptome assembly by Trinity produced 70,745,177 raw short-sequence reads and 32,463 O. faveolata transcripts, respectively. The reference transcriptome was annotated with gene ontologies, mapped to KEGG pathways, and a predicted proteome of 20,488 sequences was generated. Protein families and signaling pathways that are essential in the regulation of innate immunity across Phyla were investigated in-depth. Results were used to develop models of evolutionarily conserved Wnt, Notch, Rig-like receptor, Nod-like receptor, and Dicer signaling. O. faveolata is a coral species that has been studied widely under climate-driven stress and disease, and the present investigation provides new data on the genes that putatively regulate its immune system.
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