ArticleBrain and behavior2016
Peripheral (deep) but not periventricular MRI white matter hyperintensities are increased in clinical vascular dementia compared to Alzheimer's disease.
Article in Brain and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Machine learning applications in vascular neuroimaging for the diagnosis and prognosis of cognitive impairment and dementia: a systematic review and meta-analysis.Alzheimer's research & therapy · 2025Pooled it
- Potential neuroimaging biomarkers of pathologic brain changes in Mild Cognitive Impairment and Alzheimer's disease: a systematic review.BMC geriatrics · 2016Pooled it
- Linking cortical atrophy to white matter hyperintensities of presumed vascular origin.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Trial
- Multimodal Magnetic Resonance Imaging Signatures of White Matter Hyperintensities: Mechanistic Insights Into Pathobiological Heterogeneity.Journal of stroke · 2026Review
- Association between weekend recovery sleep and risk of incident dementia: a prospective cohort study in the UK Biobank.Journal of neurology · 2025Article
- Association of the Brain White Matter Hyperintensity with the Cognitive Performance in Middle-Aged Population.Cerebrovascular diseases (Basel, Switzerland) · 2025Article
- Cerebral white matter burden is linked to cognitive function in patients undergoing hemodialysis.Annals of medicine · 2024Article
- In vivo microstructural heterogeneity of white matter and cognitive correlates in aging using tissue compositional analysis of diffusion magnetic resonance imaging.Human brain mapping · 2024Article
- Associations between cerebral blood flow and progression of white matter hyperintensities.Frontiers in neuroimaging · 2024Article
- Sex differences in risk factors, burden, and outcomes of cerebrovascular disease in Alzheimer's disease populations.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- White matter hyperintensities influence distal cortical β-amyloid accumulation in default mode network pathways.Brain and behavior · 2023Article
- Multi-Site Cross-Site Inter-Rater and Test-Retest Reliability and Construct Validity of the MarkVCID White Matter Hyperintensity Growth and Regression Protocol.Journal of Alzheimer's disease : JAD · 2023Article
- Predicting incident dementia in cerebral small vessel disease: comparison of machine learning and traditional statistical models.Cerebral circulation - cognition and behavior · 2023Article
- Changes in Cerebral Blood Flow and Diffusion-Weighted Imaging Lesions After Intracerebral Hemorrhage.Translational stroke research · 2022Review
- Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts.Acta neuropathologica · 2022Article
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- Development of a protocol to assess within-subject, regional white matter hyperintensity changes in aging and dementia.Journal of neuroscience methods · 2021Article
- Associations of subclinical cerebral small vessel disease and processing speed in non-demented subjects: A 7-year study.NeuroImage. Clinical · 2021Article
- The Influence of Diffusion Weighted Imaging Lesions on Outcomes in Patients with Acute Spontaneous Intracerebral Hemorrhage.Neurocritical care · 2020Observational
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
background and purposeVascular dementia (VAD) is a complex diagnosis at times difficult to distinguish from Alzheimer's disease (AD). MRI scans often show white matter hyperintensities (WMH) in both conditions. WMH increase with age, and both VAD and AD are associated with aging, thus presenting an attribution conundrum. In this study, we sought to show whether the amount of WMH in deep white matter (dWMH), versus periventricular white matter (PVH), would aid in the distinction between VAD and AD, independent of age.
methodsBlinded semiquantitative ratings of WMH validated by objective quantitation of WMH volume from standardized MRI image acquisitions. PVH and dWMH were rated separately and independently by two different examiners using the Scheltens scale. Receiver operator characteristic (ROC) curves were generated using logistic regression to assess classification of VAD (13 patients) versus AD (129 patients). Clinical diagnoses were made in a specialty memory disorders clinic.
resultsUsing PVH rating alone, overall classification (area under the ROC curve, AUC) was 75%, due only to the difference in age between VAD and AD patients in our study and not PVH. In contrast, dWMH rating produced 86% classification accuracy with no independent contribution from age. A global Longstreth rating that combines dWMH and PVH gave an 88% AUC.
conclusionsIncreased dWMH indicate a higher likelihood of VAD versus AD. Assessment of dWMH on MRI scans using Scheltens and Longstreth scales may aid the clinician in distinguishing the two conditions.
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