ArticleJournal of ophthalmology2016
Ocular Surface Epithelial Thickness Evaluation in Dry Eye Patients: Clinical Correlations.
Article in Journal of ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- The Efficacy of Oral Vitamin Supplementation in Dry Eye Disease: A Systematic Review.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Pooled it
- Safety and Effectiveness of Iota-Carrageenan Eye Drops for the Treatment of Dry Eye Disease.Clinical ophthalmology (Auckland, N.Z.) · 2026Trial
- Corneal epithelial thickness profiles in dry eye patients with or without primary Sjögren's syndrome.BMC ophthalmology · 2026Article
- Changes in Corneal Epithelial Thickness and Tear Film Stability After Carboxymethyl Cellulose Use in Young Adults with High Screen Time Exposure.Clinical optometry · 2026Article
- Corneal light scattering and anterior segment findings in rheumatoid arthritis patients: a prospective study on disease monitoring.International journal of ophthalmology · 2025Article
- Corneal Epithelial Thickness in Sjogren's Disease: A Pilot Study.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- Corneal Epithelial Thickness Correlation with Dry Eye Symptom Severity: A Cross-Sectional Study.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- Assessment of corneal epithelial thickness mapping by spectral-domain optical coherence tomography.Frontiers in medicine · 2024Article
- Corneal Epithelial Thickness Mapping: A Major Review.Journal of ophthalmology · 2024Review
- Repeatability of corneal pachymetry and epithelial thickness measurements with spectral-domain optical coherence tomography (SD-OCT) and correlation to ocular surface parameters.International ophthalmology · 2023Article
- Rabbit models of dry eye disease: comparative analysis.International journal of ophthalmology · 2023Article
- Corneal Epithelial Thickness Changes After Topical Treatment of Dry Eye Disease in Primary Sjögren Syndrome.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- The effect of incomplete blinking rate on corneal epithelial remodeling after trans-PRK surgery: a six-month study.Frontiers in medicine · 2023Article
- Impact of Implementing Teleophthalmology Referral Guidelines Using the eyeSmart EMR App in 63,703 Patients from India.International journal of telemedicine and applications · 2022Article
- Impact of age, sex and refractive error on conjunctival and Tenon's capsule thickness dimensions by swept-source optical coherence tomography in a large population.International ophthalmology · 2021Article
- How Should Corneal Nerves be Incorporated Into the Diagnosis and Management of Dry Eye?Current ophthalmology reports · 2021Article
- Effects of Eye Drops Containing Hyaluronic Acid-Nimesulide Conjugates in a Benzalkonium Chloride-Induced Experimental Dry Eye Rabbit Model.Pharmaceutics · 2021Article
- Conjunctivochalasis and Tear Osmolarity Are Associated With Reduced Conjunctival Epithelial Thickness in Dry Eye.American journal of ophthalmology · 2021Article
- Corneal and Epithelial Thickness Mapping: Comparison of Swept-Source- and Spectral-Domain-Optical Coherence Tomography.Journal of ophthalmology · 2021Article
- Assessment of corneal epithelial thickness mapping in epithelial basement membrane dystrophy.PloS one · 2020Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose. To evaluate the relationship between corneal and conjunctival epithelium thickness and ocular surface clinical tests in dry eye disease (DED) patients. Patients and Methods. Fifty-four patients with DED and 32 control subjects were included. Each patient underwent an ocular surface evaluation using the ocular surface disease index (OSDI), tear film break-up time (TBUT), corneal and conjunctival staining, tear film lipid layer analysis, and Schirmer test. The central corneal (CET), limbal (LET), and bulbar conjunctival epithelium thickness (BET) were acquired using spectral-domain optical coherence tomography (SD-OCT). Results. Compared to control subjects, mean BET was significantly thicker and mean LET was significantly lower in the DED group. There was no significant difference in mean CET between the two groups. The mean LET was correlated with OSDI and TBUT. The inferior LET was correlated with OSDI, Schirmer I test, TBUT, Oxford score, and corneal sensitivity. Mean BET was correlated with OSDI and TBUT, but not with Schirmer I test and Oxford score. Conclusions. In dry eye patients, a thinner limbal epithelium and a thicker bulbar conjunctival epithelium were observed. These changes were correlated to the severity of dry eye symptoms and tear film alterations.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.