Evidence map›Paper›PMID 26925205›Full record

ArticleComputational and structural biotechnology journal2015

A case study for cloud based high throughput analysis of NGS data using the globus genomics system.

Krithika Bhuvaneshwar, Dinanath Sulakhe, Robinder Gauba, Alex Rodriguez, Ravi Madduri, Utpal Dave, Lukasz Lacinski, Ian Foster, Yuriy Gusev, Subha Madhavan

Abstract read
In one paragraph

Article in Computational and structural biotechnology journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Big Omics Data Experience.SC ... conference proceedings. SC (Conference : Supercomputing) · 2015
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Krithika BhuvaneshwarInnovation Center for Biomedical Informatics (ICBI), Georgetown University, Washington, DC 20007, USA.
Dinanath SulakheComputation Institute, University of Chicago, Argonne National Laboratory, 60637, USA; Globus Genomics, USA.
Robinder GaubaInnovation Center for Biomedical Informatics (ICBI), Georgetown University, Washington, DC 20007, USA.
Alex RodriguezComputation Institute, University of Chicago, Argonne National Laboratory, 60637, USA.
Ravi MadduriComputation Institute, University of Chicago, Argonne National Laboratory, 60637, USA; Globus Genomics, USA.
Utpal DaveComputation Institute, University of Chicago, Argonne National Laboratory, 60637, USA; Globus Genomics, USA.
Lukasz LacinskiComputation Institute, University of Chicago, Argonne National Laboratory, 60637, USA; Globus Genomics, USA.
Ian FosterComputation Institute, University of Chicago, Argonne National Laboratory, 60637, USA; Globus Genomics, USA.
Yuriy GusevInnovation Center for Biomedical Informatics (ICBI), Georgetown University, Washington, DC 20007, USA.
Subha MadhavanInnovation Center for Biomedical Informatics (ICBI), Georgetown University, Washington, DC 20007, USA.

Funding

Novel Targets in Endocrine ResponsivenessU54CA149147 · NCI · GEORGETOWN UNIVERSITY · PI WEINER, LOUIS M. · 2010 to 2014
$6.9M
MACE2K - Molecular And Clinical Extraction: A Natural Language Processing Tool for Personalized MedicineU01HG008390 · NHGRI · GEORGETOWN UNIVERSITY · PI MADHAVAN, SUBHA · 2015 to 2017
$1.5M
NCI NIH HHS U54 CA149147NHGRI NIH HHS U01 HG008390
6 · The paper itself

Abstract

Next generation sequencing (NGS) technologies produce massive amounts of data requiring a powerful computational infrastructure, high quality bioinformatics software, and skilled personnel to operate the tools. We present a case study of a practical solution to this data management and analysis challenge that simplifies terabyte scale data handling and provides advanced tools for NGS data analysis. These capabilities are implemented using the "Globus Genomics" system, which is an enhanced Galaxy workflow system made available as a service that offers users the capability to process and transfer data easily, reliably and quickly to address end-to-endNGS analysis requirements. The Globus Genomics system is built on Amazon 's cloud computing infrastructure. The system takes advantage of elastic scaling of compute resources to run multiple workflows in parallel and it also helps meet the scale-out analysis needs of modern translational genomics research.

Indexed as

Cloud computingGalaxyNext generation sequencingTranslational research

Identifiers

PMID26925205
PMCPMC4720014

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.