ArticleMolecular cytogenetics2016
Simultaneous deletion of 3'ETV6 and 5'EWSR1 genes in blastic plasmacytoid dendritic cell neoplasm: case report and literature review.
Article in Molecular cytogenetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Review
- Multiple Genomic Alterations, Including a NovelInternational journal of molecular sciences · 2023Review
- Review
- Top Ten Lymphoproliferative Lesions Not to Miss When Evaluating Oral Ulcer Biopsies.Head and neck pathology · 2023Review
- Early T-cell precursor lymphoblastic leukemia accompanied by prominent blastic plasmacytoid dendritic cell proliferation mimicking blastic plasmacytoid dendritic cell neoplasm: an exceptional case report and literature review.Journal of cancer research and clinical oncology · 2022Review
- Review
- Article
- Blastic Plasmacytoid Dendritic Cell Neoplasm: Progress in Cell Origin, Molecular Biology, Diagnostic Criteria and Therapeutic Approaches.Current medical science · 2021Review
- Blastic plasmacytoid dendritic cell neoplasm with genetic mutations in multiple epigenetic modifiers: a case report.The Journal of international medical research · 2021Article
- Dendritic Cell Leukemia: a Review.Current oncology reports · 2020Review
- How should we diagnose and treat blastic plasmacytoid dendritic cell neoplasm patients?Blood advances · 2019Article
- Blastic Plasmacytoid Dendritic Cell Neoplasm.Current hematologic malignancy reports · 2018Review
- Myelodysplastic Syndromes: Laboratory Workup in the Context of New Concepts and Classification Criteria.Current hematologic malignancy reports · 2018Review
- Treatment of blastic plasmacytoid dendritic cell neoplasm.Hematology. American Society of Hematology. Education Program · 2016Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBlastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy. Based on literature reports of limited cases, over 50 % of BPDCN have chromosomal abnormalities, but no single chromosomal change has been identified as diagnostic of this entity. CASE PRESENTATION: In this report, we present a case of BPDCN with complicated chromosomal abnormalities involving chromosomes 12 and 22 and resulting in a simultaneous partial deletion of ETV6 and EWSR1. Notably, these aberrations were identified in bone marrow myeloid precursors in the absence of bone marrow involvement by BPDCN.
conclusionAnalysis of 46 BPDCN cases with abnormal karyotypes (45 from literature reports plus this case) showed that 12p- is one of the most common structural aberrations in BPDCN. The ETV6 and CDKN1B on 12p deserve further investigations as potential markers of BPDCN.
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