Evidence map›Paper›PMID 26925135›Full record

ArticleArchives of medical science : AMS2016

Aminoguanidine cream ameliorates skin tissue microenvironment in diabetic rats.

Ming Tian, Chun Qing, Yiwen Niu, Jiaoyun Dong, Xiaozan Cao, Fei Song, Xiaoyun Ji, Shuliang Lu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of medical science : AMS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  6. The molecular biology in wound healing & non-healing wound.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2017
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ming TianShanghai Burns Institute, Rui Jin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Chun QingShanghai Burns Institute, Rui Jin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Yiwen NiuShanghai Burns Institute, Rui Jin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Jiaoyun DongShanghai Burns Institute, Rui Jin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Xiaozan CaoShanghai Burns Institute, Rui Jin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Fei SongShanghai Burns Institute, Rui Jin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Xiaoyun JiShanghai Burns Institute, Rui Jin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Shuliang LuShanghai Burns Institute, Rui Jin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Shanghai Institute of Hematology · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of the study was to explore the effect of aminoguanidine cream on the skin tissue microenvironment in diabetic rats. MATERIAL AND

methodsA total of 51 healthy male Sprague Dawley (SD) rats were randomly divided into three groups: the diabetes group (n = 18), the aminoguanidine group (n = 18) and the control group (n = 15). Rats in the diabetes group and aminoguanidine group were injected with 65 mg/kg streptozotocin to induce the diabetes model, and in the control group with citrate buffer. After successful induction of diabetes, the back hair of all rats was stripped by barium sulfide, and the aminoguanidine group was treated with aminoguanidine cream using disinfected cotton swabs twice every day for 40 days, while the diabetes and control groups were treated with the cream matrix. The pathological changes of skin were observed by HE staining, while the content of inflammatory cytokines (TNF-α, IL-8, ICAM and IL-1α) and the antioxidant indexes (T-AOC, GSH-PX, MPO MDA H2O2) were examined using commercial kits.

resultsAfter 40 days of treatment, the diabetes group manifested tissue lesions, whereas the aminoguanidine group seemed normal. Compared with the diabetes group, the content of inflammatory cytokines TNF-α, IL-8, ICAM and IL-1α was dramatically lower in the aminoguanidine group. T-AOC in all groups underwent dramatic changes and returned to normal finally. The activities of GSH-PX and MPO and content of H2O2 in the diabetes group were all higher than those in the aminoguanidine group.

conclusionsAminoguanidine may have a good systemic effect on alleviating the pathological changes of skin tissue in diabetic rats, which may be attributed to the regulation of GSH-PX, TNF-α, IL-8, ICAM and IL-1α.

Indexed as

aminoguanidinediabeticoxidative stressproinflammatory cytokinesskin tissuestreptozotocin

Identifiers

PMID26925135
PMCPMC4754380
OpenAlexW2331957061

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.