ArticleArchives of medical science : AMS2016
Expression and clinical significance of cytochrome c oxidase subunit IV in colorectal cancer patients.
Article in Archives of medical science : AMS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Aberrant Energy Metabolism in Tumors and Potential Therapeutic Targets.Genes, chromosomes & cancer · 2024Pooled it
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- Prenatal immune activation in mice induces long-term alterations in brain mitochondrial function.Translational psychiatry · 2024Article
- Copper in colorectal cancer: From copper-related mechanisms to clinical cancer therapies.Clinical and translational medicine · 2024Review
- Proteomic study of medicinal mushroom extracts reveals antitumor mechanisms in an advanced colon cancer animal model via ribosomal biogenesis, translation, and metabolic pathways.Frontiers in pharmacology · 2024Article
- Proteomic analysis of small extracellular vesicles unique to cervical cancer.Translational cancer research · 2023Article
- Bioenergetic alteration in gastrointestinal cancers: The good, the bad and the ugly.World journal of gastroenterology · 2023Review
- PICASSO allows ultra-multiplexed fluorescence imaging of spatially overlapping proteins without reference spectra measurements.Nature communications · 2022Article
- Gene expression and oxidative stress markers profile associated with toxic metals in patients with renal cell carcinoma.Molecular biology reports · 2022Article
- The Role of Mitochondria Dysfunction in Inflammatory Bowel Diseases and Colorectal Cancer.International journal of molecular sciences · 2021Review
- Ceramides Profile Identifies Patients with More Advanced Stages of Colorectal Cancer.Biomolecules · 2020Article
- Overall treatment outcome - analysis of long-term results of rectal cancer treatment on the basis of a new parameter.Archives of medical science : AMS · 2020Article
- Mitogenome germline mutations and colorectal cancer risk in Polish population.Archives of medical science : AMS · 2020Article
- How to improve the adenoma detection rate in colorectal cancer screening? Clinical factors and technological advancements.Archives of medical science : AMS · 2019Article
- Comparison of Pre- and Post-translational Expressions ofJournal of carcinogenesis & mutagenesis · 2018Article
- Augmented mitochondrial cytochrome c oxidase activity in children with iron deficiency: a tandem between iron and copper?Archives of medical science : AMS · 2018Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPrevious studies have demonstrated that the expression of cytochrome c oxidase (COX) subunits encoded by mitochondrial DNA is elevated in colorectal cancer (CRC). However, the expression of nuclear DNA-encoded COX IV and its clinical significance have not yet been investigated in CRC. MATERIAL AND
methodsWe examined COX IV expression in paired CRC samples (cancer and pericancerous tissues) by quantitative real-time polymerase chain reaction (qPCR), Western blot and immunohistochemical staining and analyzed its clinical significance.
resultsqPCR and Western blot analyses showed that COX IV expression was significantly elevated at both the mRNA (p = 0.05) and protein levels in CRC tissue samples when compared with those in paired pericancerous tissues. Immunohistochemistry also revealed that COX IV expression was significantly increased in CRC tissues (p < 0.001). Association analyses showed that there was no significant association between COX IV expression and clinical parameters of CRC patients except for gender (p = 0.017). Moreover, we did not find any association between COX IV expression and overall survival or recurrence-free survival of CRC patients. Further analysis showed no significant relationship between the expression of COX IV and proliferating cell nuclear antigen (PCNA), a marker of cell proliferation.
conclusionsOur findings suggest that elevated COX IV expression may play an important role in colorectal carcinogenesis, but not in progression, which warrants further investigation in future studies.
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