Evidence map›Paper›PMID 26925058›Full record

ArticleFrontiers in immunology2016

The Residual Innate Lymphoid Cells in NFIL3-Deficient Mice Support Suboptimal Maternal Adaptations to Pregnancy.

Selma Boulenouar, Jean-Marc Doisne, Amanda Sferruzzi-Perri, Louise M Gaynor, Jens Kieckbusch, Elisa Balmas, Hong Wa Yung, Shagayegh Javadzadeh, Léa Volmer, Delia A Hawkes and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Endometrial TGFβ signaling fosters early pregnancy development by remodeling the fetomaternal interface.American journal of reproductive immunology (New York, N.Y. : 1989) · 2023
    Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. ILC Differentiation from Progenitors in the Bone Marrow.Advances in experimental medicine and biology · 2022
    Review
  16. Interleukin-15 in Outcomes of Pregnancy.International journal of molecular sciences · 2021
    Review
  17. Review
  18. Article
  19. The role of RORγt at maternal-fetal interface during murine pregnancy.American journal of reproductive immunology (New York, N.Y. : 1989) · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Selma BoulenouarCentre for Trophoblast Research, University of Cambridge, Cambridge, UK; Department of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, National Institute for Health Research Cambridge Biomedical Research Centre, The Rosie Hospital, Cambridge, UK.
Jean-Marc DoisneDepartment of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, National Institute for Health Research Cambridge Biomedical Research Centre, The Rosie Hospital , Cambridge , UK.
Amanda Sferruzzi-PerriCentre for Trophoblast Research, University of Cambridge, Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Louise M GaynorCentre for Trophoblast Research, University of Cambridge, Cambridge, UK; Department of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, National Institute for Health Research Cambridge Biomedical Research Centre, The Rosie Hospital, Cambridge, UK.
Jens KieckbuschCentre for Trophoblast Research, University of Cambridge, Cambridge, UK; Department of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, National Institute for Health Research Cambridge Biomedical Research Centre, The Rosie Hospital, Cambridge, UK.
Elisa BalmasCentre for Trophoblast Research, University of Cambridge, Cambridge, UK; Department of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, National Institute for Health Research Cambridge Biomedical Research Centre, The Rosie Hospital, Cambridge, UK.
Hong Wa YungCentre for Trophoblast Research, University of Cambridge, Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Shagayegh JavadzadehDepartment of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, National Institute for Health Research Cambridge Biomedical Research Centre, The Rosie Hospital , Cambridge , UK.
Léa VolmerCentre for Trophoblast Research, University of Cambridge, Cambridge, UK; Department of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, National Institute for Health Research Cambridge Biomedical Research Centre, The Rosie Hospital, Cambridge, UK.
Delia A HawkesDepartment of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, National Institute for Health Research Cambridge Biomedical Research Centre, The Rosie Hospital , Cambridge , UK.
Keli PhillipsUniversity of Cambridge Metabolic Research Laboratories , Cambridge , UK.
Hugh J M BradyDepartment of Life Sciences, Imperial College London , London , UK.
Abigail L FowdenCentre for Trophoblast Research, University of Cambridge, Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Graham J BurtonCentre for Trophoblast Research, University of Cambridge, Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Ashley MoffettCentre for Trophoblast Research, University of Cambridge, Cambridge, UK; Department of Pathology, University of Cambridge, Cambridge, UK.
Francesco ColucciCentre for Trophoblast Research, University of Cambridge, Cambridge, UK; Department of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, National Institute for Health Research Cambridge Biomedical Research Centre, The Rosie Hospital, Cambridge, UK.
University of Cambridge · GBNational Institute for Health Research · GBNIHR Cambridge Biomedical Research CentreRosie Hospital · GBImperial College London · GB

Funding

British Heart Foundation FS/12/4/29254British Heart Foundation PG/09/077/27964Medical Research Council G0901737Wellcome Trust
6 · The paper itself

Abstract

Uterine NK cells are innate lymphoid cells (ILC) that populate the uterus and expand during pregnancy, regulating placental development and fetal growth in humans and mice. We have recently characterized the composition of uterine ILCs (uILCs), some of which require the transcription factor NFIL3, but the extent to which NFIL3-dependent cells support successful reproduction in mice is unknown. By mating Nfil3 (-/-) females with wild-type males, here we show the effects of NFIL3 deficiency in maternal cells on both the changes in uILCs during pregnancy and the downstream consequences on reproduction. Despite the presence of CD49a(+)Eomes(-) uILC1s and the considerable expansion of residual CD49a(+)Eomes(+) tissue-resident NK cells and uILC3s in pregnant Nfil3 (-/-) mice, we found incomplete remodeling of uterine arteries and decidua, placental defects, and fetal growth restriction in litters of normal size. These results show that maternal NFIL3 mediates non-redundant functions in mouse reproduction.

Indexed as

lymphocyte subpopulationsmouse modelsplacentapregnancyuterine NK cells

Identifiers

PMID26925058
PMCPMC4759249
OpenAlexW2292377799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.