ReviewFrontiers in physiology2016
Gut Microbiota Modification: Another Piece in the Puzzle of the Benefits of Physical Exercise in Health?
Review in Frontiers in physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 142 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Gut-Brain-axis: Targets for Improvement of Cognition in the Elderly
Physical Activity Along With a Probiotic for the Immune System and Quality of Life Improvement in Breast Cancer Survivor: A Randomised Controlled Pilot Study
Who cites it
142 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Mechanistic Investigation of Exercise Interventions in Rodent Models of Alzheimer's Disease and Prospects for Clinical Translation.Neural plasticity · 2026Pooled it
- Predictive Value of Frailty on Outcomes of Patients With Cirrhosis: Systematic Review and Meta-Analysis.JMIR medical informatics · 2025Pooled it
- Effects of Probiotic Supplementation on Sports Performance and Performance-Related Features in Athletes: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Systematic Review of the Effects of Exercise and Physical Activity on the Gut Microbiome of Older Adults.Nutrients · 2022Pooled it
- Association between grip strength and non-alcoholic fatty liver disease: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- Can Physical Activity Influence Human Gut Microbiota Composition Independently of Diet? A Systematic Review.Nutrients · 2021Pooled it
- Influence of Exercise on the Human Gut Microbiota of Healthy Adults: A Systematic Review.Clinical and translational gastroenterology · 2020Pooled it
- Trial
- Structured exercise alters the gut microbiota in humans with overweight and obesity-A randomized controlled trial.International journal of obesity (2005) · 2020Trial
- Trial
- Home-based Physical Activity Coaching, Physical Activity, and Health Care Utilization in Chronic Obstructive Pulmonary Disease. Chronic Obstructive Pulmonary Disease Self-Management Activation Research Trial Secondary Outcomes.Annals of the American Thoracic Society · 2018Trial
- Effect of a Protein Supplement on the Gut Microbiota of Endurance Athletes: A Randomized, Controlled, Double-Blind Pilot Study.Nutrients · 2018Trial
- Trial
- Impact of intensive lifestyle intervention on gut microbiota composition in type 2 diabetes: aGut microbesTrial
- The Effects of Dietary Fiber and High-Dietary-Fiber Diets on Body Weight Regulation and Lipid Metabolism in Athletes: A Narrative Review.Nutrients · 2026Review
- Gut-Joint Axis: The Role of Exercise on Gut Microbiota and Acetic Acid Modulation in Obesity-Associated Osteoarthritis Rats.Metabolites · 2026Article
- Early Biomarkers, Risk Factors, and Functional Indicators of Healthy Longevity and Their Relationship with Diet.Nutrients · 2026Review
- High-intensity exercise training alters gut microbiota to mitigate the development of experimental autoimmune encephalomyelitis.Scientific reports · 2026Article
- Postbiotics and Skeletal Muscle Health: Molecular Mechanisms and Translational Perspectives.International journal of molecular sciences · 2026Review
- Implications of Gut Microbiome in Fibromyalgia: A Scoping Review.Journal of orthopaedic case reports · 2026Article
82 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regular physical exercise provides many health benefits, protecting against the development of chronic diseases, and improving quality of life. Some of the mechanisms by which exercise provides these effects are the promotion of an anti-inflammatory state, reinforcement of the neuromuscular function, and activation of the hypothalamic-pituitary-adrenal (HPA) axis. Recently, it has been proposed that physical exercise is able to modify gut microbiota, and thus this could be another factor by which exercise promotes well-being, since gut microbiota appears to be closely related to health and disease. The purpose of this paper is to review the recent findings on gut microbiota modification by exercise, proposing several mechanisms by which physical exercise might cause changes in gut microbiota.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.