ArticleFrontiers in human neuroscience2016
Resting-State Brain and the FTO Obesity Risk Allele: Default Mode, Sensorimotor, and Salience Network Connectivity Underlying Different Somatosensory Integration and Reward Processing between Genotypes.
Article in Frontiers in human neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder.Translational psychiatry · 2022Pooled it
- Modulations of human resting brain connectivity by kisspeptin enhance sexual and emotional functions.JCI insight · 2018Trial
- Trial
- The Neuroendocrine Regulation of Reproductive Behavior and Emotional Control by Kisspeptin.The Journal of clinical endocrinology and metabolism · 2025Review
- Multimodal Neuroimaging of Obesity: From Structural-Functional Mechanisms to Precision Interventions.Brain sciences · 2025Review
- FTO variant is associated with changes in BMI, ghrelin, and brain function following bariatric surgery.JCI insight · 2024Article
- The Importance of Low-frequency Alpha (8-10 Hz) Waves and Default Mode Network in Behavioral Inhibition.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Article
- Fetal programming of human energy homeostasis brain networks: Issues and considerations.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Review
- Disrupted stepwise functional brain organization in overweight individuals.Communications biology · 2022Article
- The relationship between fat mass and obesity associated gene polymorphism rs9939609 and resting cerebral blood flow in a midlife sample with overweight and obesity.Frontiers in human neuroscience · 2022Article
- Relationship between behavioral inhibition and approach motivation systems (BIS/BAS) and intrinsic brain network connectivity in adult cannabis users.Social cognitive and affective neuroscience · 2021Article
- Brain-gut-microbiome interactions in obesity and food addiction.Nature reviews. Gastroenterology & hepatology · 2020Review
- Identification of a brain fingerprint for overweight and obesity.Physiology & behavior · 2020Article
- Differences in brain structure and function in children with theObesity science & practice · 2020Article
- MiR-495 regulates macrophage M1/M2 polarization and insulin resistance in high-fat diet-fed mice via targeting FTO.Pflugers Archiv : European journal of physiology · 2019Article
- History of early life adversity is associated with increased food addiction and sex-specific alterations in reward network connectivity in obesity.Obesity science & practice · 2019Article
- The role of mRNA mCell & bioscience · 2019Review
- FTO affects food cravings and interacts with age to influence age-related decline in food cravings.Physiology & behavior · 2018Article
- Preliminary evidence for genetic overlap between body mass index and striatal reward response.Translational psychiatry · 2018Article
- Overweight is associated with lower resting state functional connectivity in females after eliminating genetic effects: A twin study.Human brain mapping · 2017Article
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Authors and funding
13 authors.
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Abstract
Single-nucleotide polymorphisms (SNPs) of the fat mass and obesity associated (FTO) gene are linked to obesity, but how these SNPs influence resting-state neural activation is unknown. Few brain-imaging studies have investigated the influence of obesity-related SNPs on neural activity, and no study has investigated resting-state connectivity patterns. We tested connectivity within three, main resting-state networks: default mode (DMN), sensorimotor (SMN), and salience network (SN) in 30 male participants, grouped based on genotype for the rs9939609 FTO SNP, as well as punishment and reward sensitivity measured by the Behavioral Inhibition (BIS) and Behavioral Activation System (BAS) questionnaires. Because obesity is associated with anomalies in both systems, we calculated a BIS/BAS ratio (BBr) accounting for features of both scores. A prominence of BIS over BAS (higher BBr) resulted in increased connectivity in frontal and paralimbic regions. These alterations were more evident in the obesity-associated AA genotype, where a high BBr was also associated with increased SN connectivity in dopaminergic circuitries, and in a subnetwork involved in somatosensory integration regarding food. Participants with AA genotype and high BBr, compared to corresponding participants in the TT genotype, also showed greater DMN connectivity in regions involved in the processing of food cues, and in the SMN for regions involved in visceral perception and reward-based learning. These findings suggest that neural connectivity patterns influence the sensitivity toward punishment and reward more closely in the AA carriers, predisposing them to developing obesity. Our work explains a complex interaction between genetics, neural patterns, and behavioral measures in determining the risk for obesity and may help develop individually-tailored strategies for obesity prevention.
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