Evidence map›Paper›PMID 26924872›Full record

SynthesisDisease markers2016

Can the Neutrophil to Lymphocyte Ratio Be Used to Determine Gastric Cancer Treatment Outcomes? A Systematic Review and Meta-Analysis.

Jingxu Sun, Xiaowan Chen, Peng Gao, Yongxi Song, Xuanzhang Huang, Yuchong Yang, Junhua Zhao, Bin Ma, Xinghua Gao, Zhenning Wang

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Disease markers, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 10 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 10 syntheses or guidelines pooled it, 101 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jingxu SunDepartment of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang 110001, China.
Xiaowan ChenDepartment of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang 110001, China.
Peng GaoDepartment of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang 110001, China.
Yongxi SongDepartment of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang 110001, China.
Xuanzhang HuangDepartment of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang 110001, China.
Yuchong YangDepartment of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang 110001, China.
Junhua ZhaoDepartment of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang 110001, China.
Bin MaDepartment of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang 110001, China.
Xinghua GaoDepartment of Dermatology, First Hospital of China Medical University, Shenyang 110001, China.
Zhenning WangDepartment of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang 110001, China.
China Medical University · CNFirst Hospital of China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prognostic role of neutrophil to lymphocyte ratio (NLR) in gastric cancer remains controversial. We aimed to quantify the prognostic role of peripheral blood NLR in gastric cancer. A literature search was conducted in PubMed, EMBASE, and Cochrane databases. The results for overall survival (OS) and progression-free survival (PFS)/disease-free survival (DFS) are expressed as hazard ratios (HRs) with 95% confidence intervals (CIs). 19 studies with 5431 patients were eligible for final analysis. Elevated NLRs were associated with a significantly poor outcome for OS (HR = 1.98; 95% CI: 1.75-2.24, p < 0.001) and PFS (HR = 1.58; 95% CI: 1.32-1.88, p < 0.001) compared with patients who had normal NLRs. The NLR was higher for patients with late-stage compared with early-stage gastric cancer (OR = 2.76; 95% CI: 1.36-5.61, p = 0.005). NLR lost its predictive role for patients with stage IV gastric cancer who received palliative surgery (HR = 1.73; 95% CI: 0.85-3.54, p = 0.13). Our results also indicated that prognoses might be influenced by the NLR cutoff values. In conclusion, elevated pretreatment NLRs are associated with poor outcome for patients with gastric cancer. The ability to use the NLR to evaluate the status of patients may be used in the future for personalized cancer care.

Indexed as

Lymphocyte CountHumansNeutrophilsPredictive Value of TestsPrognosisStomach NeoplasmsSurvival AnalysisTreatment Outcome

Identifiers

PMID26924872
PMCPMC4746375
OpenAlexW2294582560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.