ArticlePsychological medicine2016
Aberrant intrinsic functional connectivity within and between corticostriatal and temporal-parietal networks in adults and youth with bipolar disorder.
Article in Psychological medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 50 citations in OpenAlex.
- Spatiotemporal complexity in the psychotic brain.Molecular psychiatry · 2026Article
- The Development of Hippocampal-Cortical Functional Connectivity in Infants and Toddlers.Human brain mapping · 2026Article
- Network localization of genetic risk for schizophrenia and bipolar disorder.Psychological medicine · 2025Article
- Pleiotropic effects of oxytocin receptor polymorphisms: influencing striatocortical connectivity in bipolar disorder.International journal of bipolar disorders · 2025Article
- FunMaps: a method for parcellating functional brain networks using resting-state functional MRI data.Frontiers in human neuroscience · 2024Article
- A graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults.Journal of affective disorders · 2022Article
- Enhanced inter-regional coupling of neural responses and repetition suppression provide separate contributions to long-term behavioral priming.Communications biology · 2021Article
- Dysregulation of oxytocin and dopamine in the corticostriatal circuitry in bipolar II disorder.Translational psychiatry · 2020Article
- Article
- Disturbed Resting-State Whole-Brain Functional Connectivity of Striatal Subregions in Bulimia Nervosa.The international journal of neuropsychopharmacology · 2020Article
- Article
- MRI Insights Into Adolescent Neurocircuitry-A Vision for the Future.Frontiers in human neuroscience · 2020Article
- Connectomics of bipolar disorder: a critical review, and evidence for dynamic instabilities within interoceptive networks.Molecular psychiatry · 2019Review
- Neural mechanisms of face emotion processing in youths and adults with bipolar disorder.Bipolar disorders · 2019Article
- Preliminary analysis of resting state functional connectivity in young adults with subtypes of bipolar disorder.Journal of affective disorders · 2019Article
- Overt social interaction and resting state in young adult males with autism: core and contextual neural features.Brain : a journal of neurology · 2019Article
- Sex Differences in Resting-State Functional Connectivity of the Cerebellum in Autism Spectrum Disorder.Frontiers in human neuroscience · 2019Article
- Bilateral functional connectivity at rest predicts apraxic symptoms after left hemisphere stroke.NeuroImage. Clinical · 2019Article
- Attenuated resting-state functional connectivity in patients with childhood- and adult-onset schizophrenia.Schizophrenia research · 2018Article
- Altered intrinsic functional connectivity of the cingulate cortex in children with severe temper outbursts.Development and psychopathology · 2018Article
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9 authors at 3 institutions in 1 country.
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Abstract
backgroundMajor questions remain regarding the dysfunctional neural circuitry underlying the pathophysiology of bipolar disorder (BD) in both youths and adults. In both age groups, studies implicate abnormal intrinsic functional connectivity among prefrontal, limbic and striatal areas.
methodWe collected resting-state functional magnetic resonance imaging (fMRI) data from youths and adults (ages 10-50 years) with BD (n = 39) and healthy volunteers (HV; n = 78). We identified brain regions with aberrant intrinsic functional connectivity in BD by first comparing voxel-wise mean global connectivity and then conducting correlation analyses. We used k-means clustering and multidimensional scaling to organize all detected regions into networks.
resultsAcross the brain, we detected areas of dysconnectivity in both youths and adults with BD relative to HV. There were no significant age-group × diagnosis interactions. When organized by interregional connectivity, the areas of dysconnectivity in patients with BD comprised two networks: one of temporal and parietal areas involved in late stages of visual processing, and one of corticostriatal areas involved in attention, cognitive control and response generation.
conclusionsThese data suggest that two networks show abnormal intrinsic functional connectivity in BD. Regions in these networks have been implicated previously in BD. We observed similar dysconnectivity in youths and adults with BD. These findings provide guidance for refining models of network-based dysfunction in BD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.