Evidence map›Paper›PMID 26924544›Full record

Observational studyJournal of nephrology2016

Diabetes mellitus does not affect the incidence of acute kidney injury after cardiac surgery; a nested case-control study.

Maria Moschopoulou, Foteini Ch Ampatzidou, Charalampos Loutradis, Afroditi Boutou, Charilaos-Panagiotis Koutsogiannidis, Georgios E Drosos, Pantelis A Sarafidis

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Acute kidney injury in diabetes mellitus: Epidemiology, diagnostic, and therapeutic concepts.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Maria MoschopoulouDepartment of Cardiothoracic Surgery, Papanikolaou Hospital, Thessaloniki, Greece.
Foteini Ch AmpatzidouDepartment of Cardiothoracic Surgery, Papanikolaou Hospital, Thessaloniki, Greece.
Charalampos LoutradisDepartment of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Konstantinoupoleos 49, GR54642, Thessaloniki, Greece.
Afroditi BoutouRespiratory High-Dependency Care Unit, Papanikolaou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Charilaos-Panagiotis KoutsogiannidisDepartment of Cardiothoracic Surgery, Papanikolaou Hospital, Thessaloniki, Greece.
Georgios E DrososDepartment of Cardiothoracic Surgery, Papanikolaou Hospital, Thessaloniki, Greece.
Pantelis A SarafidisDepartment of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Konstantinoupoleos 49, GR54642, Thessaloniki, Greece. psarafidis11@yahoo.gr.
G. Papanikolaou General Hospital · GRAristotle University of Thessaloniki · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute kidney injury (AKI) after cardiac surgery is a common complication associated with increased mortality. However, the heterogeneity of the definitions used results in high variance of incidence rates in the literature. Data on the effect of diabetes mellitus on AKI incidence in this setting are scarce. We thus aimed to compare the incidence of AKI (defined by the AKIN, RIFLE and KDIGO criteria) in diabetic vs. non-diabetic patients undergoing cardiac surgery.

methodsThis is a nested case-control study from a cohort of patients undergoing cardiac surgery between 1/1/2013 and 30/6/2014 in a single center. Exclusion criteria were: type-1 diabetes, end-stage renal disease, death during surgery and AKI prior to surgery. We identified 199 type-2 diabetic patients and matched them for gender, age and estimated glomerular filtration rate (eGFR) to 199 non-diabetic individuals. The incidence of AKI between the two groups was compared in the total population and in subgroups according to preoperative eGFR. Univariate and multivariate logistic regression analysis were conducted to identify factors associated with AKI.

resultsThe incidence of AKI was moderately high, but similar between the two study groups (AKIN and KDIGO: 24.1 vs. 23.1 %; p = 0.906, RIFLE: 25.1 vs. 25,1 %; p = 1.000, in diabetics and non-diabetics respectively). A trend towards increased incidence of AKI from eGFR subgroup 1 to subgroup 3a was noted in diabetic patients (p = 0.04). No significant differences were detected between the two study groups within any eGFR subgroup studied. At multivariate analysis, age [per year increase: odds ratio (OR) 1.034, 95 % confidence interval (CI) 1.001-1.068] and duration of cardiopulmonary bypass [per minute increase: OR 1.009 (1.003-1.015)] were associated with AKI. Diabetes was not related to AKI development in regression analysis [OR 1.057 (0.666-1.679)].

conclusionsIncidence of AKI after cardiac surgery is high, but diabetes is not a risk factor for AKI. Baseline renal function in diabetics is related inversely to the incidence of AKI. Age and cardiopulmonary bypass duration are independent predictors of cardiac surgery-associated AKI.

Indexed as

Acute Kidney InjuryAgedAge FactorsCardiac Surgical ProceduresCardiopulmonary BypassCase-Control StudiesChi-Square DistributionDiabetes Mellitus, Type 2FemaleGlomerular Filtration RateGreeceHeart DiseasesHumansIncidenceKidneyLogistic ModelsAcute kidney injuryCardiac surgeryChronic kidney diseaseDiabetes mellitusIncidence

Identifiers

PMID26924544
OpenAlexW2292559204

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.