ReviewAutonomic neuroscience : basic & clinical2016
Central neural control of thermoregulation and brown adipose tissue.
Review in Autonomic neuroscience : basic & clinical, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
114 citing papers in PubMed, 195 citations in OpenAlex.
- Preparing for future pandemics: enhancing serotonin activation and interpersonal warmth through music therapy to aid in adolescent depression recovery post-COVID-19: a randomized controlled trial.BMC complementary medicine and therapies · 2026Trial
- Efficacy of water spray for evaporative cooling in athletes with spinal cord injury.Spinal cord series and cases · 2019Trial
- Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets.MedComm · 2026Review
- Continuous sampling of cerebrospinal fluid from the third ventricle of the hypothalamus to identify accumulating or depleting metabolites during hibernation.The Journal of experimental biology · 2026Article
- Mechanisms of Heat-Induced Sleep Disruption in Aging: A Narrative Review.Clocks & sleep · 2026Review
- Neural Control of Homeothermy, Torpor, and Hibernation.Annual review of neuroscience · 2026Review
- Role of GIRK2 channels in morphine-induced metabolite changes in the rostral ventromedial medulla.Magnetic resonance imaging · 2026Article
- Effects of Heatwaves and Tropical Nights on Sleep in Middle-Aged and Older Adults: A Scoping Review.Clocks & sleep · 2026Review
- Hypothalamic thermoregulatory neurons divergently modulate isoflurane anesthesia via temperature dependent and independent mechanisms.iScience · 2026Article
- Temperature as a Metabolic Signal Linking Neural and Endocrine Circuits to Energy Homeostasis.International journal of molecular sciences · 2026Review
- C2CD5 in noradrenergic neurons regulates thermogenesis and lipid homeostasis via norepinephrine secretion.iScience · 2026Article
- Thyrotropin-releasing hormone neurons of different hypothalamic nuclei increase energy expenditure.Nature communications · 2026Article
- Brown adipose tissue inactivation exacerbates alcohol-induced liver steatosis, inflammation, and fibrosis.American journal of physiology. Gastrointestinal and liver physiology · 2026Article
- The poikilothermic hypothesis of sepsis.Critical care (London, England) · 2026Review
- Preoptic Neural Circuitry for Dramatic and Gentle Thermoregulation.Neuroscience bulletin · 2026Article
- Embryonic Thermal Manipulation Affects Neurodevelopment and Induces Heat Tolerance in Layers.Genes · 2025Article
- Multi-timescale Rhythmic Dynamics in Rostral Ventromedial Medulla Neurons.bioRxiv : the preprint server for biology · 2025Article
- Perspective: rheostasis revisited-hibernation and tanycytes.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Review
- Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovations.Signal transduction and targeted therapy · 2025Review
- Antipyretic Mechanism of Bai Hu Tang on LPS-Induced Fever in Rat: A Network Pharmacology and Metabolomics Analysis.Pharmaceuticals (Basel, Switzerland) · 2025Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Central neural circuits orchestrate the homeostatic repertoire that maintains body temperature during environmental temperature challenges and alters body temperature during the inflammatory response. This review summarizes the experimental underpinnings of our current model of the CNS pathways controlling the principal thermoeffectors for body temperature regulation: cutaneous vasoconstriction controlling heat loss, and shivering and brown adipose tissue for thermogenesis. The activation of these effectors is regulated by parallel but distinct, effector-specific, core efferent pathways within the CNS that share a common peripheral thermal sensory input. Via the lateral parabrachial nucleus, skin thermal afferent input reaches the hypothalamic preoptic area to inhibit warm-sensitive, inhibitory output neurons which control heat production by inhibiting thermogenesis-promoting neurons in the dorsomedial hypothalamus that project to thermogenesis-controlling premotor neurons in the rostral ventromedial medulla, including the raphe pallidus, that descend to provide the excitation of spinal circuits necessary to drive thermogenic thermal effectors. A distinct population of warm-sensitive preoptic neurons controls heat loss through an inhibitory input to raphe pallidus sympathetic premotor neurons controlling cutaneous vasoconstriction. The model proposed for central thermoregulatory control provides a useful platform for further understanding of the functional organization of central thermoregulation and elucidating the hypothalamic circuitry and neurotransmitters involved in body temperature regulation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.