Evidence map›Paper›PMID 26924315›Full record

ArticleMolecular neurobiology2017

Lifelong Nutritional Omega-3 Deficiency Evokes Depressive-Like State Through Soluble Beta Amyloid.

Maria Grazia Morgese, Paolo Tucci, Emanuela Mhillaj, Maria Bove, Stefania Schiavone, Luigia Trabace, Vincenzo Cuomo

Open access · hybridAbstract read
In one paragraph

Article in Molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Maria Grazia MorgeseDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy. mariagrazia.morgese@unifg.it.
Paolo TucciDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Emanuela MhillajPhysiology and Pharmacology, La Sapienza, University of Rome, Rome, Italy.
Maria BovePhysiology and Pharmacology, La Sapienza, University of Rome, Rome, Italy.
Stefania SchiavoneDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Luigia TrabaceDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Vincenzo CuomoPhysiology and Pharmacology, La Sapienza, University of Rome, Rome, Italy.
University of Foggia · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent evidence pointed out that the prevalence of depression has reached epidemic proportions in last decades. This increase has been linked to many environmental factors, among these the influence of dietary factors has gained great attention. In particular, it has been reported that low n-3 polyunsaturated fatty acid (n-3 PUFA) intake in diet is correlated to the development of depressive and anxiety-like symptoms. Furthermore, maternal malnutrition is a widely accepted risk factor for developing mental illness in later adulthood; among others, depression has been strongly associated to this event. On the other hand, we have previously found that acute intracerebral injection of the soluble beta amyloid 1-42 (Aβ

Indexed as

Amyloid beta-PeptidesAnimalsBrainDepressionFatty Acids, Omega-3Fatty Acids, Omega-6MaleNutritional StatusPeptide FragmentsRatsRats, WistarAmyloid beta-Peptidesamyloid beta-protein (1-42)Fatty Acids, Omega-3Fatty Acids, Omega-6Peptide FragmentsAnxietyDepressionHPA axisMonoaminesPolyunsaturated fatty acidSoluble beta amyloid

Identifiers

PMID26924315
PMCPMC5355522
OpenAlexW2291926644

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.